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CDC42BPA / MRCK
CDC42 binding protein kinase alpha (DMPK-like)
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
| Gene Name: | CDC42 binding protein kinase alpha (DMPK-like) |
| Family/Subfamily: | Protein Kinase , DMPK |
| Synonyms: | CDC42BPA, CDC42-binding kinase alpha, DMPK-like alpha, MRCKA, MRCKalpha, KIAA0451, MRCK, PK428, Ser-thr protein kinase PK428, MRCK alpha |
| Target Sequences: | NM_003607 NP_003598.2 Q5VT25 |
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