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CDC42
cell division cycle 42
CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
| Gene Name: | cell division cycle 42 |
| Synonyms: | CDC42, G25K, G25K GTP-binding protein, Growth-regulating protein, CDC42Hs, GTP-binding protein, 25kD |
| Target Sequences: | NM_001791 NP_001782.1 P60953 |
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