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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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CDC25C

cell division cycle 25C

CDC25C, a CDC25 dual specificity protein phosphatase, has been shown to affect the regulation of cell cycle control, and specifically the G2/M progression, through interaction with cdc/cyclin kinases and proliferating cell nuclear antigen (PCNA). Unlike CDC25A and CDC25B, CDC25C does not seem to have oncogenic properties. CDC25C null mutant mice are viable, fertile, and do not display obvious abnomalities. CDC25C expression is regulated by chk1, 14-3-3 protein, p53 and BRCA1, among other proteins. CDC25C is located on chromosome 5p31 near a region that is deleted in some hematologic disorders.

Gene Name: cell division cycle 25C
Family/Subfamily: Protein Phosphatase , CDC25
Synonyms: CDC25C, CDC25, CDC25C phosphatase, CDC25Hu3, Cell division cycle 25C, Phosphotyrosine phosphatase, PPP1R60, M-phase inducer phosphatase 3, Mitosis inducer CDC25
Target Sequences: NM_001790 NP_001781.2 P30307

Publications (2)

1
XJW20, a novel oxoindole derivative, induces G2/M arrest and apoptosis selectively in K562 leukemia cell line. Ye Z, Chen Z, Chen W, Xie J, Yang H, Lou Y, Yu Y. Chemico-biological interactions. 2010 183:133-41. (WB) [PubMed:19883635]
2
Ochratoxin A induces G(2) phase arrest in human gastric epithelium GES-1 cells in vitro. Cui J, Xing L, Li Z, Wu S, Wang J, Liu J, Wang J, Yan X, Zhang X. Toxicology letters. 2010 193:152-8. (WB) [PubMed:20060447]

Viewing 1-25 of 107 items
CDC25C Antibody - Anti-CDC25C antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
Mouse Monoclonal [clone 1F12] (IgG1) to Human CDC25C
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
CDC25C Antibody - Immunohistochemical analysis of CDC25C (pS216) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human CDC25C
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $265.00
CDC25C Antibody - Immunofluorescence analysis of U2OS cells.
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ICC, IF, IHC, IP, WB
Unconjugated
50µl   $235.00; 100µl   $315.00; 200µl   $425.00
CDC25C Antibody - Immunohistochemical analysis of CDC25C staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human CDC25C
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $245.00
CDC25C Antibody - Immunoperoxidase of monoclonal antibody to CDC25C on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 6 ug/ml]
Select
Mouse Monoclonal [clone 3B11] (IgG1,k) to Human CDC25C
Human
ELISA, IHC, IHC-P, IP, RNAi, WB
Unconjugated
100µg   $365.00
CDC25C Antibody
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
CDC25C Antibody
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   $575.00
Select
Mouse Monoclonal (IgG1,k) to Human CDC25C
Human
IF, IHC, IP, WB
Unconjugated, Azide-free
100µg   $1,065.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ELISA, Flo, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl   $680.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200µl   $680.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ELISA, Flo, IHC, WB
PE Conjugated
200µl   $680.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ELISA, Flo, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl   $740.00
Select
Mouse Monoclonal (IgG1,k) to Human CDC25C
Human
ICC, IHC, IP, WB
HRP Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human CDC25C
Human
ICC, IHC, IP, WB
Biotin Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human CDC25C
Human
ICC, IHC, IP, WB
FITC Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human CDC25C
Human
ICC, IHC, IP, WB
APC Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human CDC25C
Human
ICC, IHC, IP, WB
PE Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human CDC25C
Human
ICC, IHC, IP, WB
AP Conjugated
100µl   $815.00
CDC25C Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CDC25C Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human CDC25C
Human
ELISA, IF, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
CDC25C Antibody - Antibody staining MPIP3 in human testis sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH 6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Select
Mouse Monoclonal [clone 1535CT627.6.80] (IgG2a,k) to Human CDC25C
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
200µl   $325.00

Viewing 1-25 of 107 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).