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CDC25C
cell division cycle 25C
CDC25C, a CDC25 dual specificity protein phosphatase, has been shown to affect the regulation of cell cycle control, and specifically the G2/M progression, through interaction with cdc/cyclin kinases and proliferating cell nuclear antigen (PCNA). Unlike CDC25A and CDC25B, CDC25C does not seem to have oncogenic properties. CDC25C null mutant mice are viable, fertile, and do not display obvious abnomalities. CDC25C expression is regulated by chk1, 14-3-3 protein, p53 and BRCA1, among other proteins. CDC25C is located on chromosome 5p31 near a region that is deleted in some hematologic disorders.
| Gene Name: | cell division cycle 25C |
| Family/Subfamily: | Protein Phosphatase , CDC25 |
| Synonyms: | CDC25C, CDC25, CDC25C phosphatase, CDC25Hu3, Cell division cycle 25C, Phosphotyrosine phosphatase, PPP1R60, M-phase inducer phosphatase 3, Mitosis inducer CDC25 |
| Target Sequences: | NM_001790 NP_001781.2 P30307 |
Publications (2)
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