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CDC20
cell division cycle 20
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
| Gene Name: | cell division cycle 20 |
| Synonyms: | CDC20, BA276H19.3, CDC20A, p55CDC |
| Target Sequences: | NM_001255 NP_001246.2 Q12834 |
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