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CDC14B

cell division cycle 14B

Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Gene Name: cell division cycle 14B
Family/Subfamily: Protein Phosphatase , CDC14
Synonyms: CDC14B, CDC14 homolog B, Cdc14B1, Cdc14B2, Cell division cycle 14b, CDC14B3, HCDC14B
Target Sequences: NM_003671 NP_201588.1 O60729

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
CDC14B (4)
No (4)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
CDC14B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52.1 kDa
100 µg/$710
CDC14B Protein - 12.5% SDS-PAGE of human CDC14B stained with Coomassie Blue
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Wheat Germ Extract
GST
80.6 kDa
2 µg/$439
CDC14B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CDC14B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.1 kDa
20 µg/$215
Viewing 1-4 of 4 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).