CD95 / FAS

Fas cell surface death receptor

CD95 / FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

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Products

Proteins (40)

Type

Over-Expression Lysate (6)

Recombinant (34)

Target

CD95 / FAS (40)

Publications

No (40)

Tag

10His, N-terminus (1)

6His, C-terminus (4)

Fc, C-terminus (5)

GST (1)

GST, N-terminus (1)

His (7)

His, N-Terminal (1)

His,C-terminus (1)

His-GST (4)

His-MBP (2)

His-MBP, N-terminus (1)

His-T7 (1)

Human IgG1 Fc (1)

Myc-DDK (Flag) (7)

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Species

Bovine (1)

Human (22)

Mouse (8)

Pig (1)

Rat (5)

Source

293T Cells (3)

E. coli (16)

HEK 293 Cells (8)

Human (1)

Human Cells (6)

Mammalian Cells (4)

Wheat Germ Extract (2)

Purification

Purified (7)

Low Endotoxin Level

Low endotoxin level (15)

Biologically Active

Biologically active (2)

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Human CD95 / FAS Protein (Recombinant) (aa2-157) - LS-G352

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

17.6 kDa

Price:

5 µg/$268; 20 µg/$349

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Mouse CD95 / FAS Protein (Recombinant His) (Met1-Arg169) - LS-G98142

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18 kDa

Price:

100 µg/$721

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Mouse CD95 / FAS Protein (Recombinant Fc, C-terminus) (Gln22-Arg169) - LS-G40288

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.7kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Rat CD95 / FAS Protein (Recombinant His-GST) (aa21-170) - LS-G11322

Source:

E. coli

Tag:

His-GST

Molecular Weight:

48.9 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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CD95 / FAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123431

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.73 kDa

Price:

100 µg/$494

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Human CD95 / FAS Protein (Recombinant 10His, N-terminus) (Full Length) - LS-G136906

Source:

E. coli

Tag:

10His, N-terminus

Molecular Weight:

40.6 kDa

Price:

100 µg/$1,801; 20 µg/$1,247

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CD95 / FAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105969

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.6 kDa

Price:

100 µg/$494

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CD95 / FAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105974

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

7.6 kDa

Price:

100 µg/$494

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Human CD95 / FAS Protein (Recombinant Fc, C-terminus) (Met1-Glu173) - LS-G138109

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.4 kDa

Price:

100 µg/$721

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Rat CD95 / FAS Protein (Recombinant His,C-terminus) (Met1-Lys170) - LS-G138226

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18 kDa

Price:

100 µg/$721

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Rat CD95 / FAS Protein (Recombinant His) - LS-G23820

Source:

HEK 293 Cells

Tag:

His

Molecular Weight:

18.5 kDa

Price:

10 µg/$367; 50 µg/$732; 100 µg/$1,076

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Bovine CD95 / FAS Protein (Recombinant His-T7) (aa37-274) - LS-G23819

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.9 kDa

Price:

10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359

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Pig CD95 / FAS Protein (Recombinant His-GST) (aa48-281) - LS-G23852

Source:

E. coli

Tag:

His-GST

Molecular Weight:

56.9 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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Human CD95 / FAS Protein (Recombinant GST) (Full Length) - LS-G27493

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.37 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CD95 / FAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75891

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.6 kDa

Price:

20 µg/$150

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Human CD95 / FAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75890

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.73 kDa

Price:

20 µg/$150

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Human CD95 / FAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75892

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

7.6 kDa

Price:

20 µg/$150

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Human CD95 / FAS Protein (Recombinant) (aa22-171) - LS-G55919

Source:

Human

Tag:

None

Molecular Weight:

18.5kDa

Price:

50 µg/$732; 10 µg/$327; 200 µg/$1,339; 100 µg/$1,132; 1 mg/$2,614; 500 µg/$2,111; 5 mg/$5,111; 2 mg/$2,805

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Human CD95 / FAS Protein (Recombinant GST, N-terminus) (aa20-119) - LS-G57792

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CD95 / FAS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65610

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36 kDa

Price:

20 µg/$1,107

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Human CD95 / FAS Protein (Recombinant) (aa17-173) - LS-G5780

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

17.6 kDa

Price:

5 µg/$282; 100 µg/$1,186; 500 µg/$2,269

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Mouse CD95 / FAS Protein (Recombinant His) (aa22-169) - LS-G11332

Source:

E. coli

Tag:

His

Molecular Weight:

18.0 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human CD95 / FAS Protein (Recombinant His, N-Terminal) (Gln26-Asn173) - LS-G96808

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

19 kDa

Price:

10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315

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Human CD95 / FAS Protein (Recombinant His) (Met1-Asn173) - LS-G98576

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18.2 kDa

Price:

100 µg/$721

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Human CD95 / FAS Protein (Recombinant Human IgG1 Fc) (aa26-170) - LS-G3926

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~47kDa (SDS-PAGE)

Price:

50 µg/$386

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