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CD8A / CD8 Alpha

CD8a molecule

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name:	CD8a molecule
Synonyms:	CD8A, CD8a molecule, CD8a antigen, OKT8 T-cell antigen, Leu2 T-lymphocyte antigen, T8 T-cell antigen, T cell co-receptor, p32, CD8, Leu2, T-cell antigen Leu2
Target Sequences:	NM_001768 NP_001759.3 P01732

Publications (12)

Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D, Dobbins J, Devine L, Kavathas PB. Journal of immunology (Baltimore, Md. : 1950). 2008 180:7431-42. [PubMed:18490743] Related Antibodies: LS-C40806.

Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89. [PubMed:19849846] [PMC:PMC2770477] Related Antibodies: LS-C40806.

Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in guinea pigs compared to. Awasthi S, Lubinski JM, Shaw CE, Barrett SM, Cai M, Wang F, Betts M, Kingsley S, Distefano DJ, Balliet JW, Flynn JA, Casimiro DR, Bryan JT, Friedman HM. Journal of virology. 2011 85:10472-86. [PubMed:21813597] [PMC:PMC3187515] Related Antibodies: LS-C40805.

Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors. Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman DM. Molecular cancer therapeutics. 2015 14:2198-205. (ICC, Flo; Mouse, Human) [Full Text Article] [PubMed:26206336] [PMC:PMC4596766] Related Antibodies: LS-C62782.

Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation. Vrecenak JD, Pearson EG, Santore MT, Todorow CA, Li H, Radu A, Bhatti T, Peranteau WH, Johnson MP, Flake AW. Blood. 2014 124:1987-95. (ICC; Dog) [Full Text Article] [PubMed:24869940] Related Antibodies: LS-C191429.

T cells localized to the androgen-deprived prostate are TH1 and TH17 biased. Morse MD, McNeel DG. The Prostate. 2012 72:1239-47. (ICC; Human) [Full Text Article] [PubMed:22213030]

Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma. Pouliquen DL, Nawrocki-Raby B, Nader J, Blandin S, Robard M, Birembaut P, Grégoire M. Oncotarget. 2017 February;8:57552-57573. (Rat) [Full Text Article] [PubMed:28915695] [PMC:PMC5593667]

Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma. Nader JS, Abadie J, Deshayes S, Boissard A, Blandin S, Blanquart C, Boisgerault N, Coqueret O, Guette C, Grégoire M, Pouliquen DL. Oncotarget. 2018 March;9:16311-16329. [Full Text Article] [PubMed:29662647] [PMC:PMC5893242]

Targeted suppression of autoreactive CD8+<sup> T-cell activation using blocking anti-CD8 antibodies. Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L. Scientific reports. 2016 October;6:35332. [Full Text Article] [PubMed:27748447] [PMC:PMC5066216] Related Antibodies: LS-C62782.

Curcumin Treatment Identifies Therapeutic Targets within Biomarkers of Liver Colonization by Highly Invasive Mesothelioma Cells-Potential Links with Sarcomas. Daniel L Pouliquen, Alice Boissard, Cécile Henry, Stéphanie Blandin, Pascal Richomme, Olivier Coqueret, Catherine Guette. Cancers. 2020 November;12: [Full Text Article] [PubMed:33207594] [PMC:PMC7696465]

Lymphoid Organ Proteomes Identify Therapeutic Efficacy Biomarkers Following the Intracavitary Administration of Curcumin in a Highly Invasive Rat Model of Peritoneal Mesothelioma. Daniel L Pouliquen, Alice Boissard, Cécile Henry, Stéphanie Blandin, Olivier Coqueret, Catherine Guette. International journal of molecular sciences. 2021 Aug;22:8566. [Full Text Article] [PubMed:34445271] [PMC:PMC8395293]

Mesenchymal stem cell therapy stimulates endogenous host progenitor cells to improve colonic epithelial regeneration. S[Character e9]mont A, Demarquay C, Bessout R, Durand C, Benderitter M, Mathieu N. PloS one. 2013 8:e70170. [Full Text Article] [PubMed:23922953] [PMC:PMC3726425] Related Antibodies: LS-C112550.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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