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CD8A / CD8 Alpha

CD8a molecule

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: CD8a molecule
Synonyms: CD8A, CD8a molecule, CD8a antigen, OKT8 T-cell antigen, Leu2 T-lymphocyte antigen, T8 T-cell antigen, T cell co-receptor, p32, CD8, Leu2, T-cell antigen Leu2
Target Sequences: NM_001768 NP_001759.3 P01732

Publications (12)

1
Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D, Dobbins J, Devine L, Kavathas PB. Journal of immunology (Baltimore, Md. : 1950). 2008 180:7431-42. [PubMed:18490743] Related Antibodies: LS-C40806.
2
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89. [PubMed:19849846] [PMC:PMC2770477] Related Antibodies: LS-C40806.
3
Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in guinea pigs compared to. Awasthi S, Lubinski JM, Shaw CE, Barrett SM, Cai M, Wang F, Betts M, Kingsley S, Distefano DJ, Balliet JW, Flynn JA, Casimiro DR, Bryan JT, Friedman HM. Journal of virology. 2011 85:10472-86. [PubMed:21813597] [PMC:PMC3187515] Related Antibodies: LS-C40805.
4
Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors. Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman DM. Molecular cancer therapeutics. 2015 14:2198-205. (ICC, Flo; Mouse, Human) [Full Text Article] [PubMed:26206336] [PMC:PMC4596766] Related Antibodies: LS-C62782.
5
Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation. Vrecenak JD, Pearson EG, Santore MT, Todorow CA, Li H, Radu A, Bhatti T, Peranteau WH, Johnson MP, Flake AW. Blood. 2014 124:1987-95. (ICC; Dog) [Full Text Article] [PubMed:24869940] Related Antibodies: LS-C191429.
6
T cells localized to the androgen-deprived prostate are TH1 and TH17 biased. Morse MD, McNeel DG. The Prostate. 2012 72:1239-47. (ICC; Human) [Full Text Article] [PubMed:22213030]
7
Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma. Pouliquen DL, Nawrocki-Raby B, Nader J, Blandin S, Robard M, Birembaut P, Grégoire M. Oncotarget. 2017 February;8:57552-57573. (Rat) [Full Text Article] [PubMed:28915695] [PMC:PMC5593667]
8
Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma. Nader JS, Abadie J, Deshayes S, Boissard A, Blandin S, Blanquart C, Boisgerault N, Coqueret O, Guette C, Grégoire M, Pouliquen DL. Oncotarget. 2018 March;9:16311-16329. [Full Text Article] [PubMed:29662647] [PMC:PMC5893242]
9
Targeted suppression of autoreactive CD8+<sup> T-cell activation using blocking anti-CD8 antibodies. Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L. Scientific reports. 2016 October;6:35332. [Full Text Article] [PubMed:27748447] [PMC:PMC5066216] Related Antibodies: LS-C62782.
10
Curcumin Treatment Identifies Therapeutic Targets within Biomarkers of Liver Colonization by Highly Invasive Mesothelioma Cells-Potential Links with Sarcomas. Daniel L Pouliquen, Alice Boissard, Cécile Henry, Stéphanie Blandin, Pascal Richomme, Olivier Coqueret, Catherine Guette. Cancers. 2020 November;12: [Full Text Article] [PubMed:33207594] [PMC:PMC7696465]
11
Lymphoid Organ Proteomes Identify Therapeutic Efficacy Biomarkers Following the Intracavitary Administration of Curcumin in a Highly Invasive Rat Model of Peritoneal Mesothelioma. Daniel L Pouliquen, Alice Boissard, Cécile Henry, Stéphanie Blandin, Olivier Coqueret, Catherine Guette. International journal of molecular sciences. 2021 Aug;22:8566. [Full Text Article] [PubMed:34445271] [PMC:PMC8395293]
12
Mesenchymal stem cell therapy stimulates endogenous host progenitor cells to improve colonic epithelial regeneration. S[Character e9]mont A, Demarquay C, Bessout R, Durand C, Benderitter M, Mathieu N. PloS one. 2013 8:e70170. [Full Text Article] [PubMed:23922953] [PMC:PMC3726425] Related Antibodies: LS-C112550.
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Proteins (21)
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CD8A / CD8 Alpha (21)
Bind (1)
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Human CD8A / CD8 Alpha Protein (Recombinant) - LS-G136246
CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.6 kDa
10 µg/$268; 50 µg/$349
CD8A / CD8 Alpha Protein - Recombinant Cluster Of Differentiation 8a By SDS-PAGE
Select
Mouse CD8A / CD8 Alpha Protein (Recombinant His-GST) (aa27-247) - LS-G13397
E. coli
His-GST
56.8 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CD8A / CD8 Alpha Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Human CD8A / CD8 Alpha Protein (Recombinant 6His, N-terminus) (aa22-182) - LS-G57029
Mammalian Cells
6His, N-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
CD8A / CD8 Alpha Protein
Select
Mouse CD8A / CD8 Alpha Protein (Recombinant His,C-terminus) (Met1-Tyr196) - LS-G49389
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse CD8a consists of 180 amino acids and has a calculated molecular mass of 20.3 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 35 kDa protein in SDS-PAGE under reducing conditions.
50 µg/$441; 1 mg/$2,479
CD8A / CD8 Alpha Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Human CD8A / CD8 Alpha Protein (Recombinant 6His, N-terminus) (aa22-182) - LS-G57144
Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CD8A / CD8 Alpha Protein
Select
Human CD8A / CD8 Alpha Protein (Recombinant 6His, N-terminus) (Ser22-Asp182) - LS-G26502
E. coli
6His, N-terminus
19.8 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
CD8A / CD8 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
CD8A / CD8 Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126862
HEK 293 Cells
Myc-DDK (Flag)
25.67 kDa
100 µg/$494
CD8A / CD8 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
CD8A / CD8 Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118401
HEK 293 Cells
Myc-DDK (Flag)
25.67 kDa
100 µg/$494
Select
Bovine CD8A / CD8 Alpha Protein (Recombinant His-SUMO) (aa26-189) - LS-G20589
E. coli
His-SUMO
33.9 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
CD8A / CD8 Alpha Protein - 12.5% SDS-PAGE of human CD8A stained with Coomassie Blue
Select
Human CD8A / CD8 Alpha Protein (Recombinant GST) (Full Length) - LS-G27794
Wheat Germ Extract
GST
51.59 kDa
2 µg/$439
CD8A / CD8 Alpha Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Human CD8A / CD8 Alpha Protein (Recombinant 6His-SUMO, N-terminus) (aa22-182) - LS-G56147
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CD8A / CD8 Alpha Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Human CD8A / CD8 Alpha Protein (Recombinant GST, N-terminus) (aa22-131) - LS-G58032
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CD8A / CD8 Alpha Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Cow CD8A / CD8 Alpha Protein (Recombinant 6His, N-terminus) (aa26-189) - LS-G57139
Yeast
6His, N-terminus
100 µg/$679; 20 µg/$429; 1 mg/$1,973
CD8A / CD8 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human CD8A / CD8 Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79061
293T Cells
Myc-DDK (Flag)
25.67 kDa
20 µg/$150
CD8A / CD8 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human CD8A / CD8 Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79062
293T Cells
Myc-DDK (Flag)
25.67 kDa
20 µg/$150
CD8A / CD8 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human CD8A / CD8 Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79063
293T Cells
Myc-DDK (Flag)
19.4 kDa
20 µg/$150
CD8A / CD8 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
CD8A / CD8 Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102416
HEK 293 Cells
Myc-DDK (Flag)
19.4 kDa
100 µg/$494
Select
Rat CD8A / CD8 Alpha Protein (Recombinant Fc) (Met1-Tyr189) - LS-G98347
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
45 kDa
100 µg/$843
Select
Mouse CD8A / CD8 Alpha Protein (Recombinant His,C-terminus) (Met1-Tyr196) - LS-G140781
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.3 kDa
50 µg/$721
CD8A / CD8 Alpha Protein
Select
Human CD8A / CD8 Alpha Protein (Recombinant His) (aa22-198) - LS-G13394
E. coli
His
20.5 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
CD8A / CD8 Alpha Protein - Recombinant Cluster Of Differentiation 8a By SDS-PAGE
Select
Rat CD8A / CD8 Alpha Protein (Recombinant His) (aa26-236) - LS-G13399
E. coli
His
24.9 kDa
10 µg/$297; 50 µg/$540; 100 µg/$862; 200 µg/$1,061; 1 mg/$2,234; 500 µg/$1,749; 5 mg/$3,767; 2 mg/$2,425
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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