CD8

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides. To function, CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of a CD8-alpha and CD8-beta chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. Less-common homodimers of the CD8-alpha chain are also expressed on some cells.

CD8 Target Details

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Products

ELISA Kits (9)

Type

Competitive EIA (2)

Sandwich (6)

Sandwich CLIA (1)

Target

CD8 (9)

Reactivity

Human (2)

Mouse (2)

Rat (2)

Chicken (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (3)

96-Well Strip Plate (5)

Publications

No (9)

Sample Type

Plasma (8)

Serum (8)

Tissue Homogenates (1)

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Mouse CD8 (Sandwich ELISA) ELISA Kit - LS-F22890

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

1.25 - 80 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human CD8 (Sandwich ELISA) ELISA Kit - LS-F22885

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.25 - 80 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human CD8 (Sandwich ELISA) ELISA Kit - LS-F26719

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

2.5 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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Sheep CD8 (Sandwich ELISA) ELISA Kit - LS-F42413

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Chicken CD8 (Competitive EIA) ELISA Kit - LS-F54114

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

3.125 - 800 U/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$1,081

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Rat CD8 (Sandwich ELISA) ELISA Kit - LS-F22892

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

1.25 - 80 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Rat CD8 (CLIA) ELISA Kit - LS-F31182

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse CD8 (Competitive EIA) ELISA Kit - LS-F28224

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Rabbit CD8 (Sandwich ELISA) ELISA Kit - LS-F38832

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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