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CD79A / CD79 Alpha

CD79a molecule, immunoglobulin-associated alpha

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Gene Name: CD79a molecule, immunoglobulin-associated alpha
Synonyms: CD79A, CD79a antigen, Ig-alpha, MB-1, MB-1 membrane glycoprotein, Surface IgM-associated protein, MB1
Target Sequences: NM_021601 NP_001774.1 P11912

Publications (8)

1
Immunopathogenesis of severe acute respiratory disease in Zaire ebolavirus-infected pigs. Nfon CK, Leung A, Smith G, Embury-Hyatt C, Kobinger G, Weingartl HM. PloS one. 2013 8:e61904. (IHC; Porcine) [Full Text Article] [PubMed:23626748] [PMC:PMC3633953] Related Antibodies: LS-B4504.
2
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A. Verma-Gaur J, Hauser J, Grundström T. Journal of immunology (Baltimore, Md. : 1950). 2012 188:6175-83. (WB; Mouse) [Full Text Article] [PubMed:22581853] Related Antibodies: LS-C44953.
3
Association of renal tubular hyaline droplets with lymphoma in CD-1 mice. Decker JH, Dochterman LW, Niquette AL, Brej M. Toxicologic pathology. 2012 40:651-5. (WB; Human) [Full Text Article] [PubMed:22395792]
4
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies. Takada M, Parys M, Gregory-Bryson E, Vilar Saavedra P, Kiupel M, Yuzbasiyan-Gurkan V. BMC cancer. 2018 March;18:237. [Full Text Article] [PubMed:29490634] [PMC:PMC5831740] Related Antibodies: LS-B4504.
5
Shuni virus-induced meningoencephalitis after experimental infection of cattle. Franziska Sick, Angele Breithaupt, Natalia Golender, Velizar Bumbarov, Martin Beer, Kerstin Wernike. Transboundary and emerging diseases. 2020 September; [Full Text Article] [PubMed:32910551] Related Antibodies: LS-B8330.
6
Immunophenotypic Characterization of Canine Splenic Follicular-Derived B-Cell Lymphoma. Leah Stein, Cynthia Bacmeister, Kris Ylaya, Patricia Fetsch, Zengfeng Wang, Stephen M Hewitt, Matti Kiupel. Veterinary pathology. 2019 May;56:350-357. [Full Text Article] [PubMed:30636524] [PMC:PMC8191390]
7
Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells. Jayne E Wiarda, Julian M Trachsel, Sathesh K Sivasankaran, Christopher K Tuggle, Crystal L Loving. Life science alliance. 2022 October;5: [Full Text Article] [PubMed:35995567] [PMC:PMC9396248] Related Antibodies: LS-B4504.
8
Broad feedback inhibition of pre-B-cell receptor signaling components. Hauser J, Verma-Gaur J, Grundstr[Character f6]m T. Molecular immunology. 2013 Jul;54:247-53. [Full Text Article] [PubMed:23318223] Related Antibodies: LS-C44953.
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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
CD79A / CD79 Alpha (9)
No (9)
6His, C-terminus (1)
6His, N-terminus (1)
DDK (Flag)-His, C-terminus (1)
Fc (1)
GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (2)
Human (6)
Mouse (2)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Human (1)
Human Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
CD79A / CD79 Alpha Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CD79A / CD79 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
25.04 kDa
20 µg/$150
CD79A / CD79 Alpha Protein - Recombinant Immunoglobulin Associated Alpha By SDS-PAGE
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E. coli
His-T7
24.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181
CD79A / CD79 Alpha Protein - Recombinant Immunoglobulin Associated Alpha By SDS-PAGE
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E. coli
His-T7
22.5 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CD79A / CD79 Alpha Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
25 kDa
50 µg/$315; 100 µg/$365; 250 µg/$518
CD79A / CD79 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
25.04 kDa
100 µg/$494
CD79A / CD79 Alpha Protein - Recombinant Human CD79A(C-6His)
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Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
10 µg/$322; 50 µg/$546
CD79A / CD79 Alpha Protein
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HEK 293 Cells
DDK (Flag)-His, C-terminus
15 kDa
20 µg/$1,107
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
39 kDa
100 µg/$843
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).