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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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CD63
CD63 molecule
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
| Gene Name: | CD63 molecule |
| Family/Subfamily: | Tetraspan , not assigned-Tetraspan |
| Synonyms: | CD63, CD63 molecule, LAMP-3, ME491, Granulophysin, MLA1, Tetraspanin-30, Tspan-30, CD63 antigen, OMA81H, TSPAN30 |
| Target Sequences: | NM_001780 NP_001771.1 P08962 |
Publications (8)
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