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B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. The enzymatic activity of B3GAT1 enzymatic activity produces the CD57 epitope on other cell surface proteins. Please note that while CD57 is commonly used as a synonym for the B3GAT1 protein, CD57 refers to the carbohydrate epitope product, while B3GAT1 is the glucuronyltransferase enzyme that creates it.

Gene Name: beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
Synonyms: B3GAT1, CD57, GlcAT-P, GLCUATP, Glucuronosyltransferase P, HNK1, LEU7, GLCATP, NK-1, NK1, GlcUAT-P
Target Sequences: NM_018644 NP_061114.2 Q9P2W7

Publications (3)

1
T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. Kaplan RC, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Hunt P, Karim R, Kern DM, Hodis HN, Deeks SG. The Journal of infectious diseases. 2011 203:452-63. [PubMed:21220772] [PMC:PMC3071219]
2
Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults. Lutz CT, Karapetyan A, Al-Attar A, Shelton BJ, Holt KJ, Tucker JH, Presnell SR. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4590-8. [PubMed:21402893] [PMC:PMC3071442]
3
Phenotypic and Functional Characterization of Circulatory, Splenic, and Hepatic NK Cells in Simian Immunodeficiency Virus-Controlling Macaques. Vargas-Inchaustegui DA, Helmold Hait S, Chung HK, Narola J, Hoang T, Robert-Guroff M. Journal of immunology (Baltimore, Md. : 1950). 2017 November;199:3202-3211. [Full Text Article] [PubMed:28947538] [PMC:PMC5679748]

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B3GAT1 Protein - Recombinant Human B3GAT1 (N-6His)
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6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.2 kDa
10 µg/$317; 50 µg/$529
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).