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Unfortunately, the antibody (ID:88975) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CD45RA

Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA). The CD45 family consists of multiple members that are all products of a single complex gene. This gene contains 34 exons and three exons of the primary transcripts are alternatively spliced to generate up to eight different mature mRNAs and after translation eight different protein products. These three exons generate the RA, RB and RC isoforms. Various isoforms of CD45 exist: CD45RA, CD45RB, CD45RC, CD45RAB, CD45RAC, CD45RBC, CD45RO, CD45R (ABC). CD45RA is located on naive T cells and CD45RO is located on memory T cells. CD45 is also highly glycosylated. CD45R is the longest protein and migrates at 200 kDa when isolated from T cells. B cells also express CD45R with heavier glycosylation, bringing the molecular weight to 220 kDa, hence the name B220; B cell isoform of 220 kDa. B220 expression is not restricted to B cells and can also be expressed on activated T cells, on a subset of dendritic cells and other antigen-presenting cells. Naive T lymphocytes express large CD45 isoforms and are usually positive for CD45RA. Activated and memory T lymphocytes express the shortest CD45 isoform, CD45RO, which lacks RA, RB, and RC exons. This shortest isoform facilitates T cell activation. The cytoplasmic domain of CD45 is one of the largest known and it has an intrinsic phosphatase activity that removes an inhibitory phosphate group on a tyrosine kinase called Lck (in T cells) or Lyn/Fyn/Lck (in B cells) and activates it.

CD45RA Target Details

Target Name: CD45RA

Publications (8)

1
Profound enhancement of the IL-12/IL-18 pathway of IFN-gamma secretion in human CD8+ memory T cell subsets via IL-15. Smeltz RB. Journal of immunology (Baltimore, Md. : 1950). 2007 178:4786-92. [PubMed:17404259]
2
IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy. Roque S, Nobrega C, Appelberg R, Correia-Neves M. Journal of immunology (Baltimore, Md. : 1950). 2007 178:8028-35. [PubMed:17548640]
3
Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D, Dobbins J, Devine L, Kavathas PB. Journal of immunology (Baltimore, Md. : 1950). 2008 180:7431-42. [PubMed:18490743]
4
Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow. Palendira U, Chinn R, Raza W, Piper K, Pratt G, Machado L, Bell A, Khan N, Hislop AD, Steyn R, Rickinson AB, Buckley CD, Moss P. Blood. 2008 112:3293-302. [PubMed:18635810]
5
NKp80 defines and stimulates a reactive subset of CD8 T cells. Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee HG, Steinle A. Blood. 2009 113:358-69. [PubMed:18922855]
6
Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study. Iannello A, Boulassel MR, Samarani S, Debbeche O, Tremblay C, Toma E, Routy JP, Ahmad A. Journal of immunology (Baltimore, Md. : 1950). 2010 184:114-26. [PubMed:19949086]
7
Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies. Alanio C, Lemaitre F, Law HK, Hasan M, Albert ML. Blood. 2010 115:3718-25. [PubMed:20200354]
8
Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. Guerau-de-Arellano M, Smith KM, Godlewski J, Liu Y, Winger R, Lawler SE, Whitacre CC, Racke MK, Lovett-Racke AE. Brain : a journal of neurology. 2011 134:3578-89. [PubMed:22088562] [PMC:PMC3235556]
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Filtered By: None
Target
cd45ra (138)
Reactivity
Human (113)
Mouse (7)
Rat (27)
Dog (2)
Monkey (3)
Pig (3)
Rhesus monkey (2)
Application
IHC (26)
IHC-Fr (23)
IHC-P (54)
WB (12)
Flo (118)
ELISA (1)
IF (30)
IP (16)
Host
mouse (138)
Isotype
IgG1 (58)
IgG1,k (18)
IgG2a (18)
IgG2a,k (13)
IgG2b (22)
IgG2b,k (8)
IgG3 (1)
Clonality
monoclonal mc (138)
Clone
111-1C5 (3)
158.4D3 (5)
158-4D3 (2)
4KB5 (2)
BHKG-2 (3)
BL-4D4 (1)
Bu78 (2)
CA4.1D3 (1)
CDLA45RA-1 (3)
F8-11-13 (6)
HI100 (14)
JS-83 (4)
LT45RA (1)
MB1 (1)
MEM-56 (6)
MIL13 (2)
MRC OX-33 (4)
OX-33 (1)
PTPRC/1131 (3)
PTPRC/1148 (3)
PTPRC/818 (3)
SPM504 (4)
SPM568 (3)
Format
AP Conjugated (6)
APC Conjugated (5)
Azide-free (9)
Biotin Conjugated (15)
Cy5 Conjugated (3)
Cy7 Conjugated (1)
FITC Conjugated (21)
HRP Conjugated (6)
PE (4)
PE Conjugated (19)
PerCP Conjugated (2)
Ready-to-Use (9)
RPE Conjugated (2)
SPRD Conjugated (1)
Unconjugated (57)
Publications
No (138)
Showing 1-25 out of 138 results
Anti-CD45RA Antibody (clone JS-83) IHC-plus™ LS-B7881

Mouse Monoclonal [clone JS-83] (IgG1,k) to Human CD45RA
Human
Flo IHC-P
Unconjugated
Anti-CD45RA Antibody (clone MIL13, RPE) LS-C43879

Mouse Monoclonal [clone MIL13] (IgG1) to Pig CD45RA
Pig
Flo IHC-Fr IHC-P
RPE Conjugated
Anti-CD45RA Antibody (clone MRC OX-33) LS-C34520

Mouse Monoclonal [clone MRC OX-33] (IgG1) to Rat CD45RA
Rat
Flo IHC-Fr IHC-P
Unconjugated
Anti-CD45RA Antibody (clone SPM504) IHC-plus™ LS-B14796

Mouse Monoclonal [clone SPM504] (IgG2a) to Human CD45RA
Human
IHC IHC-P
Unconjugated
Anti-CD45RA Antibody (FITC) IHC-plus™ LS-B2245

Mouse Monoclonal (IgG1) to Human CD45RA
Human
Flo IHC-Fr IHC-P IP
FITC Conjugated
Anti-CD45RA Antibody (clone HI100, PE, Cy7) LS-C107386

Mouse Monoclonal [clone HI100] (IgG2b,k) to Human CD45RA
Human
Flo
PE, Cy7 Conjugated
Anti-CD45RA Antibody (clone BHKG-2) IHC-plus™ LS-B15037

Mouse Monoclonal [clone BHKG-2] (IgG1) to Human CD45RA
Human
Flo IHC-P
Unconjugated
Anti-CD45RA Antibody LS-C21836

Mouse Monoclonal (IgG2a,k) to Human CD45RA
Human
Flo IHC-Fr IHC-P
Unconjugated
Anti-CD45RA Antibody (clone MB1) IHC-plus™ LS-B5572

Mouse Monoclonal [clone MB1] (IgG1) to Human CD45RA
Human
IHC-Fr IHC-P
Unconjugated
Anti-CD45RA Antibody (clone MEM-56, APC) LS-C46195

Mouse Monoclonal [clone MEM-56] (IgG2b) to Human CD45RA
Human
Flo
APC Conjugated
Anti-CD45RA Antibody LS-C123040

Mouse Monoclonal (IgG2b) to Human CD45RA
Mouse, Rat, Human
Flo IF IHC IP WB
Unconjugated
Anti-CD45RA Antibody (HRP) LS-C544511

Mouse Monoclonal (IgG2b) to Human CD45RA
Mouse, Rat, Human
Flo IF IHC IP WB
HRP Conjugated
Anti-CD45RA Antibody (Biotin) LS-C524387

Mouse Monoclonal (IgG2b) to Human CD45RA
Mouse, Rat, Human
Flo IF IHC IP WB
Biotin Conjugated
Anti-CD45RA Antibody (FITC) LS-C534405

Mouse Monoclonal (IgG2b) to Human CD45RA
Mouse, Rat, Human
Flo IF IHC IP WB
FITC Conjugated
Anti-CD45RA Antibody (PE) LS-C652594

Mouse Monoclonal (IgG2b) to Human CD45RA
Mouse, Rat, Human
Flo IF IHC IP WB
PE Conjugated
Anti-CD45RA Antibody (APC) LS-C515701

Mouse Monoclonal (IgG2b) to Human CD45RA
Mouse, Rat, Human
Flo IF IHC IP WB
APC Conjugated
Anti-CD45RA Antibody (AP) LS-C506427

Mouse Monoclonal (IgG2b) to Human CD45RA
Mouse, Rat, Human
IF IHC IP WB
AP Conjugated
Anti-CD45RA Antibody (clone JS-83, FITC) LS-C107142

Mouse Monoclonal [clone JS-83] (IgG1,k) to Human CD45RA
Human
Flo
FITC Conjugated
Anti-CD45RA Antibody (FITC) LS-C21823

Mouse Monoclonal (IgG1) to Rat CD45RA
Rat
Flo
FITC Conjugated
Anti-CD45RA Antibody (clone MRC OX-33, PE) LS-C62772

Mouse Monoclonal [clone MRC OX-33] (IgG1) to Rat CD45RA
Rat
Flo
PE Conjugated
Anti-CD45RA Antibody LS-C21846

Mouse Monoclonal (IgG2b) to Human CD45RA
Human
Flo IHC-P IP WB
Unconjugated
Anti-CD45RA Antibody (clone MEM-56) LS-C45816

Mouse Monoclonal [clone MEM-56] (IgG2b) to Human CD45RA
Human
Flo IHC-P IP WB
Unconjugated
Anti-CD45RA Antibody (clone HI100) LS-C406959

Mouse Monoclonal [clone HI100] (IgG2a) to Human CD45RA
Human
Flo IHC WB
Unconjugated
Anti-CD45RA Antibody LS-C21815

Mouse Monoclonal (IgG1) to Human CD45RA
Human
Flo IHC-Fr IHC-P IP
Unconjugated
Anti-CD45RA Antibody (clone F8-11-13) LS-C351642

Mouse Monoclonal [clone F8-11-13] (IgG1) to Human CD45RA
Human
Flo IHC-Fr IHC-P IP
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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