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CD28

CD28 molecule

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

Gene Name:	CD28 molecule
Synonyms:	CD28, CD28 antigen, CD28 antigen (Tp44), Tp44, CD28 molecule
Target Sequences:	NM_006139 NP_006130.1 P10747

Publications (8)

A major role of PKC theta and NFkappaB in the regulation of hTERT in human T lymphocytes. Sheng WY, Chen YR, Wang TC. FEBS letters. 2006 580:6819-24. [PubMed:17141225] Related Antibodies: LS-C40963.

Ex vivo simulation of drug action: quantification of drug-induced mRNA as a bridge between preclinical and clinical trials. Mitsuhashi M. Clinical chemistry. 2007 53:148-9. [PubMed:17202503] Related Antibodies: LS-C40963.

Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities. Magatti M, De Munari S, Vertua E, Gibelli L, Wengler GS, Parolini O. Stem cells (Dayton, Ohio). 2008 26:182-92. [PubMed:17901399] Related Antibodies: LS-C40963.

Regulation of CD28 expression on CD8+ T cells by CTLA-4. Berg M, Zavazava N. Journal of leukocyte biology. 2008 83:853-63. [PubMed:18162511] Related Antibodies: LS-C40963.

Burkholderia pseudomallei infection of T cells leads to T-cell costimulation partially provided by flagellin. Ye Z, Lee CM, Sun GW, Gan YH. Infection and immunity. 2008 76:2541-50. [PubMed:18347031] [PMC:PMC2423057] Related Antibodies: LS-C40963.

HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements. Leonard JA, Filzen T, Carter CC, Schaefer M, Collins KL. Journal of virology. 2011 85:6867-81. [PubMed:21543478] [PMC:PMC3126561] Related Antibodies: LS-C40963.

Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in burmese rhesus macaques. Nomura T, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse TK, Kimura A, Matano T. Journal of virology. 2012 86:6481-90. [PubMed:22491464] [PMC:PMC3393527] Related Antibodies: LS-C40963.

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28. Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nunès JA, Borroto A, Alarcon B, Screpanti I, Tuosto L. Nature communications. 2018 March;9:1080. (Mouse) [Full Text Article] [PubMed:29540686] [PMC:PMC5852078]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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