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CD27L / CD70
CD70 molecule
CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
| Gene Name: | CD70 molecule |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | CD70, CD27LG, Ki-24 antigen, Surface antigen CD70, CD27 ligand, CD27-L, CD70 antigen, CD70 molecule, TNFSF7 |
| Target Sequences: | NM_001252 NP_001243.1 P32970 |
Publications (3)
1
Mass Cytometry Analysis Reveals that Specific Intratumoral CD4+<sup> T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma. Yang ZZ, Kim HJ, Villasboas JC, Price-Troska T, Jalali S, Wu H, Luchtel RA, Polley MC, Novak AJ, Ansell SM. Cell reports. 2019 February;26:2178-2193. [Full Text Article]
[PubMed:30784598]
[PMC:PMC6402596]
Related Antibodies: LS-A8809.
2
CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis. Tessa Dhaeze, Laurence Tremblay, Catherine Lachance, Evelyn Peelen, Stephanie Zandee, Camille Grasmuck, Lyne Bourbonnière, Sandra Larouche, Xavier Ayrignac, Rose-Marie Rébillard, Josée Poirier, Boaz Lahav, Pierre Duquette, Marc Girard, Robert Moumdjian, Alain Bouthillier, Catherine Larochelle, Alexandre Prat. Cellular & molecular immunology. 2019 Jul;16:652-665. [Full Text Article]
[PubMed:30635649]
[PMC:PMC6804668]
3
CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity. Tim Sauer, Kathan Parikh, Sandhya Sharma, Bilal Omer, David Sedloev, Qian Chen, Linus Angenendt, Christoph Schliemann, Michael Schmitt, Carsten Müller-Tidow, Stephen Gottschalk, Cliona M Rooney. Blood. 2021 July;138:318-330. [Full Text Article]
[PubMed:34323938]
[PMC:PMC8323977]
Related Antibodies: LS-A8809.
☰ Filters
Products
Proteins
(19)
Type
Over-Expression Lysate
(2)
Recombinant
(17)
Target
CD27L / CD70
(19)
Publications
No
(19)
Tag
10His, N-terminus
(1)
6His, N-terminus
(1)
Fc, C-terminus
(3)
Fc, N-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(2)
His, N-Terminal
(1)
His,N-terminus
(1)
His-GST
(1)
Mouse IgG Fc, C-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Human
(13)
Mouse
(4)
Rat
(1)
Source
293T Cells
(1)
CHO Cells
(3)
E. coli
(3)
HEK 293 Cells
(5)
Human
(2)
Human Cells
(1)
Mammalian Cells
(1)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(8)
Biologically Active
Biologically active
(3)
E. coli
6His, N-terminus
15.6 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Yeast
His
19.1 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CHO Cells
His, N-Terminal
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
10 µg/$268; 50 µg/$349
HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$1,107
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.6kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His-GST
43.1 kDa
10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181
Wheat Germ Extract
GST
46.86 kDa
2 µg/$439
CHO Cells
None
Biologically active
Less than 0.1 EU/µg protein (determined by LAL method).
The 170 amino acid recombinant protein has a predicted molecular mass of approximately 18.6 kD. The protein migrates at about 35 kD in DTT-reducing conditions by SDS-PAGE. The N-terminal amino acid is His.
25 µg/$352; 100 µg/$675
CHO Cells
None
Biologically active
The 176 amino acid recombinant protein has a predicted molecular mass of approximately 19.3 kD. The protein migrates at about 35 kD in DTT-reducing conditions by SDS-PAGE. The predicted N-terminal amino acid is His.
25 µg/$306
HEK 293 Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.9 kDa
50 µg/$444
HEK 293 Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.1 kDa
50 µg/$428
Human
Mouse IgG Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43 kDa
10 µg/$290; 50 µg/$446
Human
10His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
19 kDa
10 µg/$290; 50 µg/$446
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.6 kDa
10 µg/$281; 50 µg/$389
HEK 293 Cells
Fc, C-terminus
44 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
100 µg/$494
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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product results
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