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CD275 / B7-H2 / ICOS Ligand

inducible T-cell co-stimulator ligand

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Gene Name: inducible T-cell co-stimulator ligand
Synonyms: ICOSLG, B7RP1, B7 homolog 2, B7 homologue 2, B7-H2, B7H2, B7RP-1, CD275 antigen, ICOS ligand, GL50, ICOS-L, ICOSL, KIAA0653, B7-like protein Gl50, B7-related protein 1, CD275, LICOS
Target Sequences: AF289028 AAG01176.1 O75144

Publications (2)

1
B7-CD28 costimulatory signals control the survival and proliferation of murine and human T cells via IL-2 production. Ribot JC, Debarros A, Mancio-Silva L, Pamplona A, Silva-Santos B. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1202-8. [PubMed:22732586]
2
Combination Therapy of Novel Oncolytic Adenovirus with Anti-PD1 Resulted in Enhanced Anti-Cancer Effect in Syngeneic Immunocompetent Melanoma Mouse Model. Mariangela Garofalo, Laura Bertinato, Monika Staniszewska, Magdalena Wieczorek, Stefano Salmaso, Silke Schrom, Beate Rinner, Katarzyna Wanda Pancer, Lukasz Kuryk. Pharmaceutics. 2021 Apr;13:547. [Full Text Article] [PubMed:33919827] [PMC:PMC8070801]

☰ Filters
Products
Proteins (26)
Over-Expression Lysate (2)
Recombinant (24)
CD275 / B7-H2 / ICOS Ligand (26)
Preservative Free (1)
No (26)
6His, C-terminus (2)
DDK (Flag)-His, C-terminus (1)
Fc (1)
GST (1)
His (2)
His,C-terminus (3)
His-Fc (1)
His-T7 (2)
Human IgG1 Fc (1)
Human Mutant IgG1 Fc (1)
Mouse IgG2 Fc (2)
Mouse Mutant IgG2a Fc (1)
Myc-DDK (Flag) (3)
Human (18)
Mouse (7)
293T Cells (1)
CHO Cells (9)
E. coli (2)
HEK 293 Cells (5)
Human Cells (6)
Mammalian Cells (2)
Wheat Germ Extract (1)
Purified (8)
Low endotoxin level (15)
Biologically active (6)
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
53.7 kDa
100 µg/$661; 1 mg/$4,191
CD275 / B7-H2 / ICOS Ligand Protein
Select
CHO Cells
None
50.3 kDa
25 µg/$698
CD275 / B7-H2 / ICOS Ligand Protein
Select
CHO Cells
None
50.3 kDa
25 µg/$575
CD275 / B7-H2 / ICOS Ligand Protein
Select
CHO Cells
None
50.3 kDa
25 µg/$575
Select
CHO Cells
None
Biologically active
104.9 kDa or 90-95 kDa
100 µg/$349; 20 µg/$268
CD275 / B7-H2 / ICOS Ligand Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
33.2 kDa
20 µg/$150
CD275 / B7-H2 / ICOS Ligand Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
29 kDa
20 µg/$1,107
CD275 / B7-H2 / ICOS Ligand Protein - 12.5% SDS-PAGE of human ICOSLG stained with Coomassie Blue
Select
Wheat Germ Extract
GST
56.87 kDa
10 µg/$479; 25 µg/$670
CD275 / B7-H2 / ICOS Ligand Protein - Purified recombinant protein ICOSLG was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
33.2 kDa
20 µg/$1,107
CD275 / B7-H2 / ICOS Ligand Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
33.2 kDa
100 µg/$494
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
28 kDa
100 µg/$502
Select
CHO Cells
Human Mutant IgG1 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$470
Select
CHO Cells
Mouse IgG2 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$463
Select
CHO Cells
Human IgG1 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$463
Select
CHO Cells
Mouse IgG2 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$463
Select
CHO Cells
Mouse Mutant IgG2a Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$470
CD275 / B7-H2 / ICOS Ligand Protein - Recombinant human B7-H2-Fc Chimera is able to bind recombinant human ICOS protein in a dose dependent manner. The kD value of this binding is <5.0 nM.
Select
HEK 293 Cells
None
Less than 0.1 EU/µg protein (determined by LAL method).
This 478 amino acid recombinant protein with a C-terminal human IgG1 Fc tag has a predicted molecular mass of approximately 54 kD. The protein migrates as above 55 kD in SDS-PAGE in DTT-reducing condition and above 110 kD in non-reducing condition. The pr
10 µg/$257; 25 µg/$283; 100 µg/$355
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.72 kDa
10 µg/$288; 50 µg/$436
Select
HEK 293 Cells
His,C-terminus
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~40 kDa (SDS-PAGE)
50 µg/$442
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.1 kDa
10 µg/$281; 50 µg/$389
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.72kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.1kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
27.8 kDa
100 µg/$661; 1 mg/$4,191
Select
Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
54.3 kDa
100 µg/$661
CD275 / B7-H2 / ICOS Ligand Protein - Recombinant Inducible T-Cell Co Stimulator Ligand By SDS-PAGE
Select
E. coli
His-T7
29.1 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Viewing 1-25 of 26 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).