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CD275 / B7-H2 / ICOS Ligand

inducible T-cell co-stimulator ligand

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Gene Name: inducible T-cell co-stimulator ligand
Synonyms: ICOSLG, B7RP1, B7 homolog 2, B7 homologue 2, B7-H2, B7H2, B7RP-1, CD275 antigen, ICOS ligand, GL50, ICOS-L, ICOSL, KIAA0653, B7-like protein Gl50, B7-related protein 1, CD275, LICOS
Target Sequences: AF289028 AAG01176.1 O75144

Publications (2)

1
B7-CD28 costimulatory signals control the survival and proliferation of murine and human T cells via IL-2 production. Ribot JC, Debarros A, Mancio-Silva L, Pamplona A, Silva-Santos B. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1202-8. [PubMed:22732586]
2
Combination Therapy of Novel Oncolytic Adenovirus with Anti-PD1 Resulted in Enhanced Anti-Cancer Effect in Syngeneic Immunocompetent Melanoma Mouse Model. Mariangela Garofalo, Laura Bertinato, Monika Staniszewska, Magdalena Wieczorek, Stefano Salmaso, Silke Schrom, Beate Rinner, Katarzyna Wanda Pancer, Lukasz Kuryk. Pharmaceutics. 2021 Apr;13:547. [Full Text Article] [PubMed:33919827] [PMC:PMC8070801]

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CD275 / B7-H2 / ICOS Ligand (8)
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CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.41 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$616
CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).