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Unfortunately, the antibody (ID:156096) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CD274 / B7-H1 / PD-L1

CD274 molecule

CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. It inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. Expression of CD274 in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.

Gene Name: CD274 molecule
Synonyms: CD274, B7-H, B7 homolog 1, B7-H1, B7H1, CD274 molecule, CD274 antigen, PDCD1 ligand 1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed death ligand 1
Target Sequences: NM_014143 NP_054862.1 Q9NZQ7

Publications (8)

1
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 19:1225-31. (WB; Human) [Full Text Article] [PubMed:23307859] [PMC:PMC3752683]
2
Programmed cell death protein 1 and programmed death-ligand 1 are expressed on the surface of some small-cell lung cancer lines. Yamane H, Isozaki H, Takeyama M, Ochi N, Kudo K, Honda Y, Yamagishi T, Kubo T, Kiura K, Takigawa N. American journal of cancer research. 2015 5:1553-7. (Flo; Human) [PubMed:26101718] [PMC:PMC4473331] Related Antibodies: LS-C188354.
3
Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells. Karakhanova S, Link J, Heinrich M, Shevchenko I, Yang Y, Hassenpflug M, Bunge H, von Ahn K, Brecht R, Mathes A, Maier C, Umansky V, Werner J, Bazhin AV. Oncoimmunology. 2015 4:e998519. (Flo; Mouse) [Full Text Article] [PubMed:26137414] [PMC:PMC4485765]
4
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma. Beldi-Ferchiou A, Lambert M, Dogniaux S, Vély F, Vivier E, Olive D, Dupuy S, Levasseur F, Zucman D, Lebbé C, Sène D, Hivroz C, Caillat-Zucman S. Oncotarget. 2016 7:72961-72977. (WB; Human) [Full Text Article] [PubMed:27662664] [PMC:PMC5341956]
5
EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1a and STAT3. Koh J, Jang JY, Keam B, Kim S, Kim MY, Go H, Kim TM, Kim DW, Kim CW, Jeon YK, Chung DH. Oncoimmunology. 2016 5:e1108514. (Flo; Human) [Full Text Article] [PubMed:27141364] Related Antibodies: LS-C188353.
6
Induction of PD-L1 Expression by the EML4-ALK Oncoprotein and Downstream Signaling Pathways in Non-Small Cell Lung Cancer. Ota K, Azuma K, Kawahara A, Hattori S, Iwama E, Tanizaki J, Harada T, Matsumoto K, Takayama K, Takamori S, Kage M, Hoshino T, Nakanishi Y, Okamoto I. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:4014-21. (WB; Human) [Full Text Article] [PubMed:26019170]
7
Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer. Azuma K, Ota K, Kawahara A, Hattori S, Iwama E, Harada T, Matsumoto K, Takayama K, Takamori S, Kage M, Hoshino T, Nakanishi Y, Okamoto I. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2014 25:1935-40. (WB; Human) [Full Text Article] [PubMed:25009014]
8
Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice. Sham CW, Chan AM, Kwong JM, Caprioli J, Nusinowitz S, Chen B, Lee JG, Gandhi NM, Francisco LM, Sharpe AH, Chen L, Braun J, Gordon LK. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2012 32:227-37. (WB; Human) [Full Text Article] [PubMed:22635166]
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Filtered By: None
Target
cd274-b7-h1-pd-l1 (154)
Reactivity
Human (96)
Mouse (62)
Rat (33)
Bovine (3)
Chimpanzee (6)
Cynomolgus (1)
Orangutan (3)
Pig (3)
Application
IHC (58)
IHC-Fr (5)
IHC-P (14)
WB (89)
Flo (51)
ELISA (32)
Func (1)
ICC (11)
IF (8)
IP (12)
Peptide-ELISA (2)
Host
rabbit (82)
mouse (49)
goat (2)
rat (21)
Isotype
IgG (55)
IgG1 (19)
IgG1,k (7)
IgG2a (12)
IgG2a,k (2)
IgG2a,l (3)
IgG2b (10)
Clonality
monoclonal mc (72)
polyclonal pc (82)
Clone
[8E12] (1)
10F.9G2 (4)
1-111A (2)
12K56 (1)
1B12 (1)
1D7 (1)
1F11 (1)
27A2 (2)
29E.2A3 (3)
2B12 (1)
2C7 (1)
2D6 (1)
2E3 (1)
4D4 (1)
4F2 (1)
6H10 (1)
7D2A10 (1)
ANC6H1 (5)
MIH2 (4)
MIH3 (2)
MIH5 (3)
MIH6 (2)
PDL1.A6 (1)
PDL1.D1 (1)
RBT-PDL1 (2)
Format
AP Conjugated (5)
APC (5)
APC Conjugated (10)
Azide-free (3)
Biotin Conjugated (20)
Cy3 Conjugated (5)
Cy7 Conjugated (5)
FITC Conjugated (19)
HRP Conjugated (12)
Low Endotoxin (2)
PE Conjugated (15)
Ready-to-Use (1)
RPE Conjugated (2)
Unconjugated (61)
Epitope
aa34-241 (18)
aa24-234 (10)
aa48-290 (10)
aa261-290 (8)
C-Terminus (4)
aa192-241 (3)
Internal (2)
aa19-238 (2)
aa100-114 (1)
aa166-176 (1)
aa45-290 (1)
Publications
No (152)
Yes (2)
Showing 1-25 out of 154 results
Anti-CD274 / B7-H1 / PD-L1 Antibody (aa261-290) IHC-plus™ LS-B10562
Anti-B7-H1 / PD-L1 / CD274 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10562 dilution 1:100.
CD274 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The CD274 antibody detected the CD274 protein (arrow).

Rabbit Polyclonal to Human CD274 / B7-H1 / PD-L1
Human
IHC IHC-P WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone MIH5) LS-C107430
Surface staining of mouse splenocytes with anti-mouse B7-H1 (MIH5) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

Rat Monoclonal [clone MIH5] (IgG2a,l) to Mouse CD274 / B7-H1 / PD-L1
Mouse
Flo IHC IHC-Fr
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone 27A2) LS-C179481
Flow Cytometry Image

Mouse Monoclonal [clone 27A2] (IgG2b)
Human
Flo IHC IHC-P
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone ANC6H1) LS-C134636
Flow cytometry of B7-H1 / PD-L1 / CD274 antibody

Mouse Monoclonal [clone ANC6H1] (IgG1,k) to Human CD274 / B7-H1 / PD-L1
Human
ELISA Flo
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone ANC6H1, Biotin) LS-C134637
Flow cytometry of B7-H1 / PD-L1 / CD274 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone ANC6H1] (IgG1,k) to Human CD274 / B7-H1 / PD-L1
Human
ELISA Flo
Biotin Conjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone ANC6H1, Azide-free) LS-C134638
Flow cytometry of B7-H1 / PD-L1 / CD274 antibody This image was taken for the unmodified form of this product. Other forms have not been tested.

Mouse Monoclonal [clone ANC6H1] (IgG1,k) to Human CD274 / B7-H1 / PD-L1
Human
ELISA Flo
Unconjugated, Azide-free
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone 2C7) LS-C338364
Anti-CD274 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CD274.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD274 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD274.

Mouse Monoclonal [clone 2C7] (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
IF WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone MIH3) LS-C179364

Mouse Monoclonal [clone MIH3] (IgG1) to Human CD274 / B7-H1 / PD-L1
Flo
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone 29E.2A3) LS-C40827
Human peripheral blood lymphocytes stained with purified 29E.2A3, followed by biotinylated anti-mouse IgG and Sav-PE

Mouse Monoclonal [clone 29E.2A3] (IgG2b) to Human CD274 / B7-H1 / PD-L1
Human
Flo
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone MIH2) LS-C58200
Peripheral Human lymphocytes stained with Mouse anti Human CD274.

Mouse Monoclonal [clone MIH2] (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
Flo
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone 27A2) LS-C179482

Mouse Monoclonal [clone 27A2] (IgG2b)
Human
Flo
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (FITC) LS-C128033

Mouse Monoclonal (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
Flo
FITC Conjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (PE) LS-C125334

Mouse Monoclonal (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
Flo
PE Conjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (aa34-241) LS-C314620
Western blot of recombinant B7-H1 / PD-L1 / CD274.

Rabbit Polyclonal (IgG) to Mouse CD274 / B7-H1 / PD-L1
Mouse
IHC WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone MIH2, FITC) LS-C188353
Flow cytometry of human peripheral blood monocytes with Mouse anti-Human CD274:FITC This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone MIH2] (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
Flo
FITC Conjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone 4D4) LS-C338366
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD274 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD274.

Mouse Monoclonal [clone 4D4] (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone 2E3) LS-C338370
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD274 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD274.

Mouse Monoclonal [clone 2E3] (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone 2B12) LS-C338375
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD274 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD274.

Mouse Monoclonal [clone 2B12] (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone MIH2, RPE) LS-C188354
Flow cytometry of human peripheral blood monocytes with Mouse anti-Human CD274:RPE This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone MIH2] (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
Flo
RPE Conjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (aa48-290) LS-C296046
Western blot of recombinant B7-H1 / PD-L1 / CD274.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Mouse CD274 / B7-H1 / PD-L1
Mouse, Rat
IHC WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody LS-C331610
Western blot analysis of extracts of various cell lines, using CD274 antibody.
Western blot analysis of extracts of various cell lines.

Rabbit Polyclonal (IgG) to Human CD274 / B7-H1 / PD-L1
Mouse, Human
IHC WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone RBT-PDL1) LS-C348568
IHC of HPV on FFPE LSIL of the Cervix.

Rabbit Monoclonal [clone RBT-PDL1] (IgG) to Human CD274 / B7-H1 / PD-L1
Human
IHC IHC-Fr IHC-P
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (aa261-290, Azide-free, HRP) LS-C249630

Rabbit Polyclonal (IgG) to Human CD274 / B7-H1 / PD-L1
Human
ELISA WB
HRP Conjugated, Azide-free
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone 1B12) LS-C338359
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD274 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD274.

Mouse Monoclonal [clone 1B12] (IgG1) to Human CD274 / B7-H1 / PD-L1
Human
WB
Unconjugated
Anti-CD274 / B7-H1 / PD-L1 Antibody (clone RBT-PDL1, Ready-to-Use) LS-C348566
IHC of HPV on FFPE LSIL of the Cervix. This image was taken for the unmodified form of this product. Other forms have not been tested.

Rabbit Monoclonal [clone RBT-PDL1] (IgG) to Human CD274 / B7-H1 / PD-L1
Human
IHC IHC-Fr IHC-P
Unconjugated, Ready-to-Use

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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