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CD22

CD22 molecule

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Gene Name: CD22 molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: CD22, CD22 molecule, CD22 antigen, SIGLEC2, SIGLEC-2, T-cell surface antigen Leu-14, B-cell receptor CD22, BL-CAM
Target Sequences: NM_001771 NP_001762.2 P20273

Publications (1)

1
Epitope mapping and key amino acid identification of anti-CD22 immunotoxin CAT-8015 using hybrid -lactamase display. Bannister D, Popovic B, Sridharan S, Giannotta F, File P, Yilmaz N, Minter R. Protein engineering, design & selection : PEDS. 2011 24:351-60. (IP) [PubMed:21159620] [PMC:PMC3049344]

☰ Filters
Products
Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
CD22 (12)
No (12)
6His, C-terminus (1)
AVI-6His, C-terminus (1)
Fc (1)
Fc, C-terminus (1)
His (2)
His,C-terminus (2)
Myc-DDK (Flag) (3)
Human (8)
Mouse (3)
293T Cells (1)
CHO Cells (1)
E. coli (1)
HEK 293 Cells (3)
Human (2)
Human Cells (2)
Mammalian Cells (2)
Purified (2)
Low endotoxin level (8)
Biologically active (1)
CD22 Protein - Recombinant Sialic Acid Binding Ig Like Lectin 2 By SDS-PAGE
Select
E. coli
His
26.7 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
CD22 Protein - Purified recombinant protein CD22 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
95.2 kDa
20 µg/$1,107
CD22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
76.2 kDa
20 µg/$215
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
102.3 kDa
10 µg/$288; 50 µg/$436
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
76.2 kDa
10 µg/$288; 50 µg/$436
CD22 Protein - Recombinant Human B-cell Receptor CD22/Siglec-2/CD22 (C-6His) Biotinylated
Select
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
78 kDa
20 µg/$416; 100 µg/$910
CD22 Protein - Recombinant Mouse B-cell Receptor CD22/Siglec-2/CD22 (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
77.3 kDa
10 µg/$276; 50 µg/$405
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
58.5 kDa
100 µg/$721
CD22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
76.2 kDa
100 µg/$710
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
78.8 kDa
100 µg/$721
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
104.3 kDa
100 µg/$721
Viewing 26-12 of 12 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).