CD209 / DC-SIGN

CD209 molecule

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

CD209 / DC-SIGN (8)

Publications

No (8)

Tag

Fc, N-terminus (2)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Human (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human CD209 / DC-SIGN Protein (Recombinant His, N-Terminal) (aa70-404) - LS-G24384

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

42.0 kDa

Price:

10 µg/$275; 50 µg/$407; 100 µg/$652; 200 µg/$812; 1 mg/$1,893; 500 µg/$1,444; 5 mg/$2,843; 2 mg/$2,077

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Mouse CD209 / DC-SIGN Protein (Recombinant His-T7) (aa115-238) - LS-G24385

Source:

E. coli

Tag:

His-T7

Molecular Weight:

18.0 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human CD209 / DC-SIGN Protein (Recombinant GST, N-terminus) (aa271-380) - LS-G62357

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CD209 / DC-SIGN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81343

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$150

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Human CD209 / DC-SIGN Protein (Recombinant GST) (Full Length) - LS-G33523

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.2 kDa

Price:

10 µg/$479; 25 µg/$670

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CD209 / DC-SIGN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101731

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

100 µg/$494

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Human CD209 / DC-SIGN Protein (Recombinant Fc, N-terminus) (Lys62-Ala404) - LS-G138110

Source:

HEK 293 Cells

Tag:

Fc, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

65.8 kDa

Price:

100 µg/$721

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Human CD209 / DC-SIGN Protein (Recombinant Fc, N-terminus) - LS-G146129

Source:

Human

Tag:

Fc, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

65.3 kDa

Price:

10 µg/$290; 50 µg/$446

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