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CD20

membrane-spanning 4-domains, subfamily A, member 1

CD20 is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

Gene Name: membrane-spanning 4-domains, subfamily A, member 1
Synonyms: MS4A1, B-lymphocyte antigen CD20, B1, Bp35, CD20, CD20 antigen, CD20 receptor, LEU-16, CVID5
Target Sequences: NM_021950 NP_690605.1 P11836

Publications (4)

1
BDNF and its receptors in human myasthenic thymus: implications for cell fate in thymic pathology. Berzi A, Ayata CK, Cavalcante P, Falcone C, Candiago E, Motta T, Bernasconi P, Hohlfeld R, Mantegazza R, Meinl E, Farina C. Journal of neuroimmunology. 2008 197:128-39. (ICC) [PubMed:18555538]
2
Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Staphylococcus aureus Osteomyelitis. Gowrishankar Muthukrishnan, Alexandra Wallimann, Javier Rangel-Moreno, Karen L de Mesy Bentley, Maria Hildebrand, Karen Mys, H Mark Kenney, Eric T Sumrall, John L Daiss, Stephan Zeiter, R Geoff Richards, Edward M Schwarz, T Fintan Moriarty. Frontiers in immunology. 2021 April;12:651515. [Full Text Article] [PubMed:33815412] [PMC:PMC8012494] Related Antibodies: LS-B2605.
3
PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8+ T cells in lymphoid tissue. Sheikh Abdul Rahman, Bhrugu Yagnik, Alexander P Bally, Kristen N Morrow, Shelly Wang, Thomas H Vanderford, Gordon J Freeman, Rafi Ahmed, Rama Rao Amara. Science immunology. 2021 September;6:eabh3034. [Full Text Article] [PubMed:34516743] [PMC:PMC8500359] Related Antibodies: LS-B11144.
4
Tumor-initiating properties of breast cancer and melanoma cells in vivo are not invariably reflected by spheroid formation in vitro, but can be increased by long-term culturing as adherent monolayers. Kuch V, Schreiber C, Thiele W, Umansky V, Sleeman JP. International journal of cancer. Journal international du cancer. 2013 Feb;132:E94-105. [Full Text Article] [PubMed:22907275] Related Antibodies: LS-C13105.
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).