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CD1D

CD1d molecule

CD1D is a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.

Gene Name: CD1d molecule
Synonyms: CD1D, CD1D antigen, d polypeptide, R3, R3G1, CD1d antigen, CD1d molecule, Thymocyte antigen CD1D
Target Sequences: NM_001766 NP_001757.1 P15813

Publications (1)

1
Increased cytoplasmatic expression of cancer immune surveillance receptor CD1d in anaplastic thyroid carcinomas. Weber F, Junger H, Werner JM, Velez Char N, Rejas C, Schlitt HJ, Hornung M. Cancer medicine. 2019 November;8:7065-7073. [Full Text Article] [PubMed:31560833] [PMC:PMC6853836]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).