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CD19

CD19 molecule

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Gene Name: CD19 molecule
Synonyms: CD19, B-lymphocyte antigen CD19, CD19 molecule, Differentiation antigen CD19, T-cell surface antigen Leu-12, B4, CD19 antigen, CVID3
Target Sequences: NM_001770 NP_001761.3 P15391

Publications (7)

1
Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes. Walker JD, Maier CL, Pober JS. Journal of immunology (Baltimore, Md. : 1950). 2009 182:1548-59. [PubMed:19155503] [PMC:PMC2630120] Related Antibodies: LS-C40960.
2
Mouse mesenchymal stem cells can support human hematopoiesis both in vitro and in vivo: the crucial role of neural cell adhesion molecule. Wang X, Hisha H, Mizokami T, Cui W, Cui Y, Shi A, Song C, Okazaki S, Li Q, Feng W, Kato J, Ikehara S. Haematologica. 2010 95:884-91. [PubMed:20015889] [PMC:PMC2878784] Related Antibodies: LS-C40960.
3
Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody. Joseph A, Zheng JH, Chen K, Dutta M, Chen C, Stiegler G, Kunert R, Follenzi A, Goldstein H. Journal of virology. 2010 84:6645-53. [PubMed:20410262] [PMC:PMC2903239] Related Antibodies: LS-C40960.
4
Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival. Punt S, Corver WE, van der Zeeuw SA, Kielbasa SM, Osse EM, Buermans HP, de Kroon CD, Jordanova ES, Gorter A. Oncotarget. 2015 6:38681-94. (WB; Human) [Full Text Article] [PubMed:26299617] [PMC:PMC4770729] Related Antibodies: LS-C174739.
5
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells. Baptista MA, Keszei M, Oliveira M, Sunahara KK, Andersson J, Dahlberg CI, Worth AJ, Liedén A, Kuo IC, Wallin RP, Snapper SB, Eidsmo L, Scheynius A, Karlsson MC, Bouma G, Burns SO, Forsell MN, Thrasher AJ, Nylén S, Westerberg LS. Nature communications. 2016 7:12175. (Flo; Mouse) [Full Text Article] [PubMed:27425374] [PMC:PMC4960314]
6
The Neuroregenerative Capacity of Olfactory Stem Cells Is Not Limitless: Implications for Aging. Child KM, Herrick DB, Schwob JE, Holbrook EH, Jang W. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018 August;38:6806-6824. [Full Text Article] [PubMed:29934351] [PMC:PMC6070664] Related Antibodies: LS-C122956.
7
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Marco Ruella, Jun Xu, David M Barrett, Joseph A Fraietta, Tyler J Reich, David E Ambrose, Michael Klichinsky, Olga Shestova, Prachi R Patel, Irina Kulikovskaya, Farzana Nazimuddin, Vijay G Bhoj, Elena J Orlando, Terry J Fry, Hans Bitter, Shannon L Maude, Bruce L Levine, Christopher L Nobles, Frederic D Bushman, Regina M Young, John Scholler, Saar I Gill, Carl H June, Stephan A Grupp, Simon F Lacey, J Joseph Melenhorst. Nature medicine. 2018 Oct;24:1499-1503. [Full Text Article] [PubMed:30275568] [PMC:PMC6511988] Related Antibodies: LS-C134319.
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).