Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Lactosylceramide (LacCer, CDw17) is a bioactive lipid found on the plasma membrane of phagocytes and epithelial cells with functions in the immune response and inflammation. It is important as a precursor to sulfatides and gangliosides. In the immune system, LacCer is involved in superoxide generation and also in neutrophil migration and phagocytosis via LacCer-enriched lipid rafts (PMID 26609196, PMID 27729551). Furthermore, lactosylceramide has the ability to bind to some microorganisms (PMID 30175814). There is evidence that lactosylceramide contributes to multiple sclerosis disease progression (PMID 25295934).
|Target Name:||CD17 / Lactosylceramide|
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