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CD16

CD16 is a low affinity Fc receptor. It is a CD molecule found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. It can be used to isolate populations of these cells by antibodies directed towards CD16, using fluorescent-activated cell sorting or magnetic-activated cell sorting. CD16 has been identified as Fc receptors Fc?RIIIa (CD16a) and Fc?RIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies which then activates the NK cell for antibody-dependent cell-mediated cytotoxicity. A lack of CD16 in a given population of neutrophils may indicate prematurity, as could be caused by a left-shift due to neutrophilic leukocytosis induced by tissue necrosis or bacterial infection.

CD16 Target Details

Target Name:

CD16

Publications (4)

A Csf1r-EGFP Transgene Provides a Novel Marker for Monocyte Subsets in Sheep. Pridans C, Davis GM, Sauter KA, Lisowski ZM, Corripio-Miyar Y, Raper A, Lefevre L, Young R, McCulloch ME, Lillico S, Milne E, Whitelaw B, Hume DA. Journal of immunology (Baltimore, Md. : 1950). 2016 197:2297-305. (Flo; Human) [Full Text Article] [PubMed:27521343] [PMC:PMC5009875]

Fatal accelerated rejection with a prominent natural killer cell infiltrate in a heart transplant recipient with peripartum cardiomyopathy. Javaheri A, Wang AR, Luning Prak E, Lal P, Goldberg LR, Kamoun M. Transplant immunology. 2017 (Flo; Human) [Full Text Article] [PubMed:29101003] Related Antibodies: LS-B8501.

Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization. Domínguez-Soto A, de las Casas-Engel M, Bragado R, Medina-Echeverz J, Aragoneses-Fenoll L, Martín-Gayo E, van Rooijen N, Berraondo P, Toribio ML, Moro MA, Cuartero I, Castrillo A, Sancho D, Sánchez-Torres C, Bruhns P, Sánchez-Ramón S, Corbí AL. Journal of immunology (Baltimore, Md. : 1950). 2014 193:5181-9. (Flo; Human) [Full Text Article] [PubMed:25326025] Related Antibodies: LS-C202099.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry10<sup> Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA12<sup> Arthritis and Tissue Degeneration, Hospital for Special Surgery, New York, NY, USA14<sup> Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA16<. Fan Zhang , Kevin Wei, Kamil Slowikowski , Chamith Y Fonseka , Deepak A Rao, Stephen Kelly, Susan M Goodman , Darren Tabechian, Laura B Hughes, Karen Salomon-Escoto, Gerald F M Watts, A Helena Jonsson, Javier Rangel-Moreno, Nida Meednu, Cristina Rozo, William Apruzzese, Thomas M Eisenhaure, David J Lieb, David L Boyle, Arthur M Mandelin nd, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Brendan F Boyce, Edward DiCarlo, E. Nature immunology. 2019 Jul;;20:928-942. [Full Text Article] [PubMed:31061532] [PMC:PMC6602051] Related Antibodies: LS-B8501.

Mouse CD16 Protein (Recombinant His,C-terminus) (Leu32-Thr215) - LS-G139386

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21.9 kDa

Price:

10 µg/$281; 50 µg/$389

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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