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CD144 / CDH5 / VE Cadherin

cadherin 5, type 2 (vascular endothelium)

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Gene Name:	cadherin 5, type 2 (vascular endothelium)
Family/Subfamily:	Cadherin , not assigned-Cadherin
Synonyms:	CDH5, 7B4, 7B4 antigen, CD144, Cadherin-5, Endothelial-specific cadherin, Vascular endothelial cadherin, VE-cadherin, VEC, CD144 antigen, VE Cadherin
Target Sequences:	NM_001795 NP_001786.2 P33151

Publications (7)

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RD, Mueller M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NW. Nature medicine. 2015 21:777-85. (Func; Mouse) [Full Text Article] [PubMed:26076038] [PMC:PMC4496295]

Neuromedin B Restores Erectile Function by Protecting the Cavernous Body and the Nitrergic Nerves from Injury in a Diabetic Rat Model. Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Yamada D, Homma Y. PloS one. 2015 10:e0133874. (ICC, WB; Human, Rat) [Full Text Article] [PubMed:26207818] [PMC:PMC4514746]

A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter. Umeno J, Hisamatsu T, Esaki M, Hirano A, Kubokura N, Asano K, Kochi S, Yanai S, Fuyuno Y, Shimamura K, Hosoe N, Ogata H, Watanabe T, Aoyagi K, Ooi H, Watanabe K, Yasukawa S, Hirai F, Matsui T, Iida M, Yao T, Hibi T, Kosaki K, Kanai T, Kitazono T, Matsumoto T. PLoS genetics. 2015 11:e1005581. (IHC, IF; Human) [Full Text Article] [PubMed:26539716] [PMC:PMC4634957] Related Antibodies: LS-B3780.

New continuous-flow total artificial heart and vascular permeability. Feng J, Cohn WE, Parnis SM, Sodha NR, Clements RT, Sellke N, Frazier OH, Sellke FW. The Journal of surgical research. 2015 199:296-305. (WB; Human) [Full Text Article] [PubMed:26188957] [PMC:PMC4636951] Related Antibodies: LS-C177974.

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2a. Mira E, Carmona-Rodríguez L, Pérez-Villamil B, Casas J, Fernández-Aceñero MJ, Martínez-Rey D, Martín-González P, Heras-Murillo I, Paz-Cabezas M, Tardáguila M, Oury TD, Martín-Puig S, Lacalle RA, Fabriás G, Díaz-Rubio E, Mañes S. Nature communications. 2018 February;9:575. (Human) [Full Text Article] [PubMed:29422508] [PMC:PMC5805714]

Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension. Bhagwani AR, Hultman S, Farkas D, Moncayo R, Dandamudi K, Zadu AK, Cool CD, Farkas L. PloS one. 2019 March;14:e0213890. [Full Text Article] [PubMed:30883593] [PMC:PMC6422269] Related Antibodies: LS-C313199.

Soluble RAGE attenuates AngII-induced endothelial hyperpermeability by disrupting HMGB1-mediated crosstalk between AT1R and RAGE. Jisu Jeong, Jiye Lee, Juyeon Lim, Soyoung Cho, Soyoung An, Myungeun Lee, Nara Yoon, Miran Seo, Soyeon Lim, Sungha Park. Experimental & molecular medicine. 2019 Sep;51:44211. [Full Text Article] [PubMed:31562296] [PMC:PMC6802637] Related Antibodies: LS-C357312.

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