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CD14

CD14 molecule

In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

Gene Name: CD14 molecule
Synonyms: CD14, CD14 molecule, CD14 antigen
Target Sequences: NM_000591 NP_000582.1 P08571

Publications (6)

1
TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57. [PubMed:17641010] Related Antibodies: LS-C41087.
2
C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes. Santer DM, Hall BE, George TC, Tangsombatvisit S, Liu CL, Arkwright PD, Elkon KB. Journal of immunology (Baltimore, Md. : 1950). 2010 185:4738-49. [PubMed:20844193] [PMC:PMC3065655] Related Antibodies: LS-C41087.
3
LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. Hsu RY, Chan CH, Spicer JD, Rousseau MC, Giannias B, Rousseau S, Ferri LE. Cancer research. 2011 71:1989-98. (IHC) [PubMed:21363926]
4
LPS stimulation of purified human platelets is partly dependent on plasma soluble CD14 to secrete their main secreted product, soluble-CD40-Ligand. Damien P, Cognasse F, Eyraud MA, Arthaud CA, Pozzetto B, Garraud O, Hamzeh-Cognasse H. BMC immunology. 2015 16:3. (Flo; Human) [Full Text Article] [PubMed:25636826] [PMC:PMC4322959] Related Antibodies: LS-C140133.
5
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, Kohlmeyer J, Renn M, Phung B, Aymans P, Schmidt T, Hornung V, Davidson I, Goding CR, Jönsson G, Landsberg J, Tüting T, Hölzel M. Nature communications. 2015 6:8755. (ICC; Human) [Full Text Article] [PubMed:26530832] [PMC:PMC4659938]
6
EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS. Weaver KF, Stokes JV, Gunnoe SA, Follows JS, Shafer L, Ammari MG, Archer TM, Thomason JM, Mackin AJ, Pinchuk LM. Journal of veterinary medicine and research. 2014 1: (Flo; Canine) [PubMed:25950023] [PMC:PMC4418640] Related Antibodies: LS-C43762.
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☰ Filters
Products
Proteins (26)
Over-Expression Lysate (4)
Recombinant (22)
CD14 (26)
No (26)
6His, C-terminus (2)
6His, N-terminus (2)
Fc (1)
Fc, C-terminus (1)
Fc, N-terminus (1)
GST (2)
His (5)
His,C-terminus (1)
His-Fc (1)
His-GST (1)
Myc-DDK (Flag) (6)
Human (17)
Mouse (3)
Pig (1)
Rat (3)
293T Cells (2)
CHO Cells (3)
E. coli (6)
HEK 293 Cells (7)
Human Cells (5)
Mammalian Cells (2)
Wheat Germ Extract (1)
Purified (10)
Low endotoxin level (11)
Biologically active (1)
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.81kD
10 µg/$257; 50 µg/$355; 500 µg/$1,439; 1 mg/$2,055
CD14 Protein - Recombinant Cluster Of Differentiation 14 By SDS-PAGE
Select
E. coli
His
41.3 kDa
10 µg/$279; 50 µg/$470; 100 µg/$750; 200 µg/$936; 1 mg/$2,046
CD14 Protein - 12.5% SDS-PAGE of human CD14 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
66.99 kDa
10 µg/$461; 25 µg/$611
Select
E. coli
GST
62.5 kD
1 mg/$1,152; 100 µg/$400; 20 µg/$307
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
36.5 kDa
50 µg/$372; 100 µg/$473
Select
Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
63.5 kDa
100 µg/$473; 200 µg/$677
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
62.2 kDa
100 µg/$473; 200 µg/$677
CD14 Protein - Purified recombinant protein CD14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
38 kDa
20 µg/$922
CD14 Protein - Purified recombinant protein CD14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
38 kDa
20 µg/$922
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.8 kDa
100 µg/$473; 200 µg/$677
Select
HEK 293 Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
62.4 kDa
50 µg/$420; 100 µg/$492
CD14 Protein
Select
HEK 293 Cells
Fc, C-terminus
63 kDa
20 µg/$922
CD14 Protein - IL-8 induction on THP-1 cells stimulated with LPS+ CD14.
Select
CHO Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 333 amino acid recombinant protein has a predicted molecular mass of approximately 35.8 kD. The DTT-reduced and non-reduced glycosylated protein migrate at approximately 50-60 kD and 40-55 kD respectively by SDS-PAGE. The N-terminal amino acid is Thr.
10 µg/$249; 25 µg/$285; 100 µg/$392
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.8 kDa
10 µg/$259; 50 µg/$358
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
36.7 kDa
100 µg/$473; 200 µg/$677
CD14 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
37.5 kDa
10 µg/$255; 50 µg/$305; 100 µg/$355
CD14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
40.08 kDa
20 µg/$125
CD14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
40.08 kDa
20 µg/$125
CD14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
40.08 kDa
100 µg/$435
CD14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
40.08 kDa
100 µg/$435
CD14 Protein
Select
E. coli
His
50 µg/$351; 250 µg/$694
Select
CHO Cells
None
Less than 0.1 ng/µg of protein.
50.0 kDa
10 µg/$466
Select
CHO Cells
None
Less than 0.1 ng/µg of protein.
50.0 kDa
10 µg/$556
CD14 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, N-terminus
100 µg/$950; 20 µg/$421; 500 µg/$2,466
CD14 Protein - Recombinant Cluster Of Differentiation 14 By SDS-PAGE
Select
E. coli
His-GST
69.9 kDa
10 µg/$294; 50 µg/$555; 100 µg/$886; 200 µg/$1,063; 1 mg/$2,344
Viewing 1-25 of 26 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).