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CD14
CD14 molecule
In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
| Gene Name: | CD14 molecule |
| Synonyms: | CD14, CD14 molecule, CD14 antigen |
| Target Sequences: | NM_000591 NP_000582.1 P08571 |
Publications (11)
1
TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57.
[PubMed:17641010]
Related Antibodies: LS-C41087.
2
C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes. Santer DM, Hall BE, George TC, Tangsombatvisit S, Liu CL, Arkwright PD, Elkon KB. Journal of immunology (Baltimore, Md. : 1950). 2010 185:4738-49.
[PubMed:20844193]
[PMC:PMC3065655]
Related Antibodies: LS-C41087.
3
LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. Hsu RY, Chan CH, Spicer JD, Rousseau MC, Giannias B, Rousseau S, Ferri LE. Cancer research. 2011 71:1989-98. (IHC)
[PubMed:21363926]
☰ Filters
Products
Proteins
(24)
Type
Over-Expression Lysate
(4)
Recombinant
(20)
Target
CD14
(24)
Publications
No
(24)
Tag
6His, C-terminus
(2)
6His, N-terminus
(2)
Fc
(1)
Fc, C-terminus
(1)
Fc, N-terminus
(1)
GST
(2)
His
(5)
His,C-terminus
(1)
His-Fc
(1)
His-GST
(1)
Myc-DDK (Flag)
(6)
Species
Human
(16)
Mouse
(2)
Pig
(1)
Rat
(3)
Source
293T Cells
(2)
CHO Cells
(1)
E. coli
(6)
HEK 293 Cells
(7)
Human Cells
(5)
Mammalian Cells
(2)
Wheat Germ Extract
(1)
Purification
Purified
(8)
Low Endotoxin Level
Low endotoxin level
(9)
Biologically Active
Biologically active
(1)
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.81kD
10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157
E. coli
His
41.3 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
HEK 293 Cells
Myc-DDK (Flag)
40.08 kDa
100 µg/$494
HEK 293 Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
62.4 kDa
100 µg/$502
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.8 kDa
100 µg/$611; 1 mg/$4,191
HEK 293 Cells
Fc, C-terminus
63 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
40.08 kDa
100 µg/$494
E. coli
GST
62.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Wheat Germ Extract
GST
66.99 kDa
10 µg/$479; 25 µg/$670
Mammalian Cells
6His, N-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
63.5 kDa
100 µg/$793
HEK 293 Cells
Myc-DDK (Flag)
38 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
38 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
40.08 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
40.08 kDa
20 µg/$150
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
36.5 kDa
100 µg/$483
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
62.2 kDa
100 µg/$793
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.8 kDa
10 µg/$269; 50 µg/$368
CHO Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 333 amino acid recombinant protein has a predicted molecular mass of approximately 35.8 kD. The DTT-reduced and non-reduced glycosylated protein migrate at approximately 50-60 kD and 40-55 kD respectively by SDS-PAGE. The N-terminal amino acid is Thr.
10 µg/$268; 25 µg/$310; 100 µg/$436
E. coli
6His, N-terminus
37.5 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
E. coli
His-GST
69.9 kDa
10 µg/$303; 50 µg/$582; 100 µg/$930; 200 µg/$1,126; 1 mg/$2,327; 500 µg/$1,837; 5 mg/$4,061; 2 mg/$2,519
E. coli
His
18.9 kDa
10 µg/$300; 50 µg/$562; 100 µg/$897; 200 µg/$1,096; 1 mg/$2,284; 500 µg/$1,796; 5 mg/$3,921; 2 mg/$2,476
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
36.7 kDa
100 µg/$793
Viewing 1-24
of 24
product results
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