In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
|Gene Name:||CD14 molecule|
|Synonyms:||CD14, CD14 molecule, CD14 antigen|
|Target Sequences:||NM_000591 NP_000582.1 P08571|
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