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CD14

CD14 molecule

In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

Gene Name:	CD14 molecule
Synonyms:	CD14, CD14 molecule, CD14 antigen
Target Sequences:	NM_000591 NP_000582.1 P08571

Publications (11)

TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57. [PubMed:17641010] Related Antibodies: LS-C41087.

C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes. Santer DM, Hall BE, George TC, Tangsombatvisit S, Liu CL, Arkwright PD, Elkon KB. Journal of immunology (Baltimore, Md. : 1950). 2010 185:4738-49. [PubMed:20844193] [PMC:PMC3065655] Related Antibodies: LS-C41087.

LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. Hsu RY, Chan CH, Spicer JD, Rousseau MC, Giannias B, Rousseau S, Ferri LE. Cancer research. 2011 71:1989-98. (IHC) [PubMed:21363926]

LPS stimulation of purified human platelets is partly dependent on plasma soluble CD14 to secrete their main secreted product, soluble-CD40-Ligand. Damien P, Cognasse F, Eyraud MA, Arthaud CA, Pozzetto B, Garraud O, Hamzeh-Cognasse H. BMC immunology. 2015 16:3. (Flo; Human) [Full Text Article] [PubMed:25636826] [PMC:PMC4322959] Related Antibodies: LS-C140133.

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, Kohlmeyer J, Renn M, Phung B, Aymans P, Schmidt T, Hornung V, Davidson I, Goding CR, Jönsson G, Landsberg J, Tüting T, Hölzel M. Nature communications. 2015 6:8755. (ICC; Human) [Full Text Article] [PubMed:26530832] [PMC:PMC4659938]

MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy. Julia Reinhardt, Jennifer Landsberg, Jonathan L Schmid-Burgk, Bartomeu Bibiloni Ramis, Tobias Bald, Nicole Glodde, Dorys Lopez-Ramos, Arabella Young, Shin Foong Ngiow, Daniel Nettersheim, Hubert Schorle, Thomas Quast, Waldemar Kolanus, Dirk Schadendorf, Georgina V Long, Jason Madore, Richard A Scolyer, Antoni Ribas, Mark J Smyth, Paul C Tumeh, Thomas Tüting, Michael Hölzel. Cancer research. 2017 September;77:4697-4709. [Full Text Article] [PubMed:28652246]

Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects. Ibon Eguíluz-Gracia, Anthony Bosco, Ralph Dollner, Guro Reinholt Melum, Maria H Lexberg, Anya C Jones, Sinan Ahmed Dheyauldeen, Patrick G Holt, Espen S Bækkevold, Frode Lars Jahnsen. The Journal of allergy and clinical immunology. 2016 June;137:1872-1881.e12. [Full Text Article] [PubMed:26851967] Related Antibodies: LS-C140133.

Increased plasma CD14 levels 1 year postpartum in women with pre-eclampsia during pregnancy: a case-control plasma proteomics study. Antigoni Manousopoulou , Fatma S Abad , Diana J Garay-Baquero, Brian R Birch, Bas B van Rijn, Bashir A Lwaleed , Spiros D Garbis. Nutrition & diabetes. 2020 Jan;10:2. [Full Text Article] [PubMed:32066653] [PMC:PMC7026086]

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD3910<sup> Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fquintana@rics.bwh.harvard.edu. Maisa C Takenaka, Galina Gabriely, Veit Rothhammer, Ivan D Mascanfroni, Michael A Wheeler, Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Jessica Kenison, Emily C Tjon, Andreia Barroso, Tyler Vandeventer, Kalil Alves de Lima, Sonja Rothweiler, Lior Mayo, Soufiene Ghannam, Stephanie Zandee, Luke Healy, David Sherr, Mauricio F Farez , Alexandre Prat, Jack Antel, David A Reardon, Hailei Zhang, Simon C Robson, Gad Getz, Howard L Weiner, Francisco J Quintana. Nature neuroscience. 2019 May;;22:729-740. [Full Text Article] [PubMed:30962630] [PMC:PMC8052632] Related Antibodies: LS-B3012.

P2Y12 receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases. Alexander Mildner, Hao Huang, Josefine Radke, Werner Stenzel, Josef Priller. Glia. 2017 Feburary;65:375-387. [Full Text Article] [PubMed:27862351] Related Antibodies: LS-B3012.

EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS. Weaver KF, Stokes JV, Gunnoe SA, Follows JS, Shafer L, Ammari MG, Archer TM, Thomason JM, Mackin AJ, Pinchuk LM. Journal of veterinary medicine and research. 2014 1: (Flo; Canine) [PubMed:25950023] [PMC:PMC4418640] Related Antibodies: LS-C43762.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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