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CD121b / IL1R2

interleukin 1 receptor, type II

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Gene Name: interleukin 1 receptor, type II
Family/Subfamily: Interleukin
Synonyms: IL1R2, CD121b, CD121b antigen, CDw121b, IL-1RT-2, IL1R2c, Interleukin-1 receptor beta, Interleukin-1 receptor type II, IL-1R-beta, Antigen CDw121b, IL-1 type II receptor, IL-1R-2, IL-1RT2, IL1RB, Interleukin-1 receptor type 2
Target Sequences: NM_004633 NP_004624.1 P27930

Publications (1)

1
Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration. Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi, Torben Lykke Sørensen. Immunity & ageing : I & A. 2017 Jul;14:18. [Full Text Article] [PubMed:28769990] [PMC:PMC5531023] Related Antibodies: LS-C139986.

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Products
Proteins (21)
Over-Expression Lysate (4)
Recombinant (17)
CD121b / IL1R2 (21)
No (21)
6His, C-terminus (4)
Fc, C-terminus (6)
GST, N-terminus (1)
His (2)
His,C-terminus (1)
Myc-DDK (Flag) (6)
Human (12)
Mouse (6)
Rat (1)
293T Cells (2)
HEK 293 Cells (7)
Human Cells (7)
Mammalian Cells (4)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (14)
CD121b / IL1R2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CD121b / IL1R2 Protein - Purified recombinant protein IL1R2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
43.9 kDa
20 µg/$1,107
CD121b / IL1R2 Protein - Purified recombinant protein IL1R2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
43.9 kDa
20 µg/$1,107
CD121b / IL1R2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
45.42 kDa
20 µg/$150
CD121b / IL1R2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
43.9 kDa
20 µg/$150
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Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
38.4 kDa
100 µg/$721
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
39.3 kDa
100 µg/$843
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64.9kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.6kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64.5kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
CD121b / IL1R2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
43.9 kDa
100 µg/$494
CD121b / IL1R2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
45.42 kDa
100 µg/$494
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64.5 kDa
100 µg/$843
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.6 kDa
100 µg/$793; 1 mg/$4,191
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64.5 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.0 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64.9 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.6 kDa
10 µg/$281; 50 µg/$389
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
65.1 kDa
100 µg/$793
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
39.7 kDa
100 µg/$793
Viewing 1-21 of 21 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).