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CCRL2

chemokine (C-C motif) receptor-like 2

CCRL2 is a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.

Gene Name: chemokine (C-C motif) receptor-like 2
Family/Subfamily: GPCR , Chemokine
Synonyms: CCRL2, CCR11, Chemokine receptor X, CRAM, CRAM-A, CRAM-B, CKRX, C-C chemokine receptor-like 2, Chemokine receptor CCR11, HCR
Target Sequences: NM_003965 NP_003956.2 O00421

Publications (3)

1
The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage. Annalisa Del Prete, Laura Martínez-Muñoz, Cristina Mazzon, Lara Toffali, Francesca Sozio, Lorena Za, Daniela Bosisio, Luisa Gazzurelli, Valentina Salvi, Laura Tiberio, Chiara Liberati, Eugenio Scanziani, Annunciata Vecchi, Carlo Laudanna, Mario Mellado, Alberto Mantovani, Silvano Sozzani. Blood. 2017 September;130:1223-1234. [Full Text Article] [PubMed:28743719] Related Antibodies: LS-C184185.
2
Chemerin Regulates Epithelial Barrier Function of Mammary Glands in Dairy Cows. Yutaka Suzuki, Sachi Chiba, Koki Nishihara, Keiichi Nakajima, Akihiko Hagino, Won-Seob Kim, Hong-Gu Lee, Tomonori Nochi, Toru Suzuki, Sang-Gun Roh. Animals: an open access journal from MDPI. 2021 Nov;11:3194. [Full Text Article] [PubMed:34827927] [PMC:PMC8614423] Related Antibodies: LS-A1094.
3
The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia. Theodoros Karantanos, Patric Teodorescu, Brandy Perkins, Ilias Christodoulou, Christopher Esteb, Ravi Varadhan, Eric Helmenstine, Trivikram Rajkhowa, Bogdan C Paun, Challice Bonifant, W Brian Dalton, Lukasz P Gondek, Alison R Moliterno, Mark J Levis, Gabriel Ghiaur, Richard J Jones. Science advances. 2022 Feburary;8:eabl8952. [Full Text Article] [PubMed:35179961] [PMC:PMC8856621] Related Antibodies: LS-C382506.

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CCRL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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40.8 kDa
100 µg/$494
CCRL2 Protein - 12.5% SDS-PAGE of human CCRL2 stained with Coomassie Blue
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58.3 kDa
2 µg/$439
CCRL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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20 µg/$150
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).