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CCR10 / GPR2

chemokine (C-C motif) receptor 10

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).

Gene Name: chemokine (C-C motif) receptor 10
Family/Subfamily: GPCR , Chemokine
Synonyms: CCR10, C-C CKR-10, CC-CKR-10, CCR-10, C-C chemokine receptor type 10, CC chemokine receptor 10, G-protein coupled receptor 2, GPR2, G protein-coupled receptor 2
Target Sequences: NM_016602 NP_057686.2 P46092

Publications (1)

1
POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease. Buelow BJ, Rohlfing M, Jung F, Douglas GJ, Grayson MH. Immunity, inflammation and disease. 2017 June;5:98-108. [Full Text Article] [PubMed:28474501] [PMC:PMC5418136] Related Antibodies: LS-C35337.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).