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CCNE2 / Cyclin E2

cyclin E2

CCNE2 / Cyclin E2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.

Gene Name: cyclin E2
Synonyms: CCNE2, Cyclin E2, CYCE2, G1/S-specific cyclin-E2
Target Sequences: AF091433 AAC80528.1 O96020

Publications (1)

1
Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc. Caldon CE, Sergio CM, Schtte J, Boersma MN, Sutherland RL, Carroll JS, Musgrove EA. Molecular and cellular biology. 2009 29:4623-39. (IP) [PubMed:19564413] [PMC:PMC2725719]

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Proteins (3)
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CCNE2 / Cyclin E2 (3)
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HEK 293 Cells (1)
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CCNE2 / Cyclin E2 Protein - 12.5% SDS-PAGE of human CCNE2 stained with Coomassie Blue
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Wheat Germ Extract
GST
66.88 kDa
10 µg/$479; 25 µg/$670
CCNE2 / Cyclin E2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.6 kDa
20 µg/$150
CCNE2 / Cyclin E2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
46.6 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).