CCNE1 / Cyclin E1

cyclin E1

CCNE1 / Cyclin E1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

CCNE1 / Cyclin E1 (9)

Application

Bind (1)

ELISA (1)

Func (1)

SDS-PAGE (1)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-GST (2)

His-GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (7)

Mouse (1)

Source

293T Cells (1)

Baculovirus (5)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (5)

Biologically Active

Biologically active (1)

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Human CCNE1 / Cyclin E1 Protein (Recombinant His-GST, N-terminus) (Met1-Ala410) - LS-G48121

Source:

Baculovirus

Tag:

His-GST, N-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human CCNE1/GST chimera consists of 647 amino acids and has a calculated molecular mass of 75 kDa. It migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.

Price:

100 µg/$480

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Human CCNE1 / Cyclin E1 Protein (Recombinant GST) (Full Length) - LS-G27777

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.84 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CCNE1 / Cyclin E1 Protein (Recombinant) (Met1-Ala410) - LS-G98521

Source:

Baculovirus

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.2 kDa

Price:

100 µg/$843

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Human CCNE1 / Cyclin E1 Protein (Recombinant GST, N-terminus) (aa311-410) - LS-G58019

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CCNE1 / Cyclin E1 Protein (Recombinant His) (Met1-Ala410) - LS-G97233

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49.3 kDa

Price:

50 µg/$721

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Human CCNE1 / Cyclin E1 Protein (Recombinant His-GST) (Met1-Ala410) - LS-G97234

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75 kDa

Price:

100 µg/$843

Select

Mouse CCNE1 / Cyclin E1 Protein (Recombinant His-GST) (Met1-Glu408) - LS-G98071

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

74.8 kDa

Price:

100 µg/$843

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Human CCNE1 / Cyclin E1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76013

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.9 kDa

Price:

20 µg/$150

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CCNE1 / Cyclin E1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99382

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.9 kDa

Price:

100 µg/$494

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