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CCND3 / Cyclin D3

cyclin D3

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Gene Name: cyclin D3
Synonyms: CCND3, D3-type cyclin, G1/S-specific cyclin D3, G1/S-specific cyclin-D3, Cyclin D3
Target Sequences: NM_001760 NP_001751.1 P30281

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Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
CCND3 / Cyclin D3 (7)
No (7)
GST (1)
GST, N-terminus (2)
GST, N-terminus + His, C-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (6)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
CCND3 / Cyclin D3 Protein - Recombinant Cyclin D3 By SDS-PAGE
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E. coli
His, N-Terminal
36.3 kDa
50 µg/$432; 10 µg/$279; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
CCND3 / Cyclin D3 Protein
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E. coli
GST, N-terminus + His, C-terminus
60.3 kDa
50 µg/$419
CCND3 / Cyclin D3 Protein - 12.5% SDS-PAGE of human CCND3 stained with Coomassie Blue
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Wheat Germ Extract
GST
58.9 kDa
10 µg/$479; 25 µg/$670
CCND3 / Cyclin D3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
32.3 kDa
20 µg/$150
CCND3 / Cyclin D3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
CCND3 / Cyclin D3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CCND3 / Cyclin D3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.3 kDa
100 µg/$494
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).