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CCND1 / Cyclin D1

cyclin D1

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Gene Name: cyclin D1
Synonyms: CCND1, B-cell lymphoma 1 protein, BCL-1 oncogene, B-cell CLL/lymphoma 1, BCL-1, Cyclin D1, G1/S-specific cyclin-D1, U21B31, PRAD1, BCL1, D11S287E, PRAD1 oncogene
Target Sequences: NM_053056 NP_444284.1 P24385

Publications (4)

1
Unraveling the therapeutic potential of GANT61/Dactolisib combination as a novel prostate cancer modality. Mohamed Youssef, Nermine Moussa, Maged W Helmy, Medhat Haroun. Medical oncology (Northwood, London, England). 2022 July;39:143. [Full Text Article] [PubMed:35834137] [PMC:PMC9283339]
2
GANT61/BI-847325 combination: a new hope in lung cancer treatment. Abdel Halim M El-Kishky, Nermine Moussa, Maged W Helmy, Medhat Haroun. Medical oncology (Northwood, London, England). 2022 July;39:144. [Full Text Article] [PubMed:35834029] [PMC:PMC9283175]
3
Quercetin potentiates 5-fluorouracil effects in human colon cancer cells through targeting the Wnt/ß-catenin signalling pathway: the role of miR-27a. Ghada T Terana, Mohamed M Abd-Alhaseeb, Gamal A Omran, Tarek M Okda. Contemporary oncology (Poznan, Poland). 2022 November;26:229-238. [Full Text Article] [PubMed:36381675] [PMC:PMC9641630]
4
Bmi-1 in gallbladder carcinoma: Clinicopathology and mechanism of regulation of human gallbladder carcinoma proliferation. Jiao K, Jiang W, Zhao C, Su D, Zhang H. Oncology letters. 2019 August;18:1365-1371. [Full Text Article] [PubMed:31423199] [PMC:PMC6607302] Related Antibodies: LS-B3452.
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ELISA Kits (30)
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CCND1 / Cyclin D1 (30)
Human (9)
Mouse (9)
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Cell Lysates (5)
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Serum (14)
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CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$764
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CCND1 / Cyclin D1 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CCND1 / Cyclin D1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CCND1 / Cyclin D1 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,182; 1000 Wells/$1,747
CCND1 / Cyclin D1 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
CCND1 / Cyclin D1 ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
CCND1 / Cyclin D1 ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
CCND1 / Cyclin D1 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CCND1 / Cyclin D1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CCND1 / Cyclin D1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CCND1 / Cyclin D1 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CCND1 / Cyclin D1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CCND1 / Cyclin D1 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CCND1 / Cyclin D1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$856
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).