CCN4 / WISP1

WNT1 inducible signaling pathway protein 1

CCN4 / WISP1 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.

☰ Filters

Products

Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

CCN4 / WISP1 (11)

Publications

No (11)

Tag

GST (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Mouse (2)

Source

293T Cells (2)

E. coli (5)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

Biologically Active

Biologically active (2)

Select

Human CCN4 / WISP1 Protein (Recombinant) - LS-G137593

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein.

Molecular Weight:

The 345 amino acids recombinant protein has a predicted molecular mass of 38.1 kD. The predicted N-terminal amino acid is Thr.

Price:

20 µg/$352

Select

Human CCN4 / WISP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89215

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.33 kDa

Price:

20 µg/$150

Select

Human CCN4 / WISP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89216

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.3 kDa

Price:

20 µg/$150

Select

CCN4 / WISP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117031

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.33 kDa

Price:

100 µg/$494

Select

Human CCN4 / WISP1 Protein (Recombinant His-T7) (aa216-347) - LS-G25808

Source:

E. coli

Tag:

His-T7

Molecular Weight:

18.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

Select

Mouse CCN4 / WISP1 Protein (Recombinant His) (aa216-347) - LS-G25809

Source:

E. coli

Tag:

His

Molecular Weight:

16.3 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

Select

Human CCN4 / WISP1 Protein (Recombinant GST) (Full Length) - LS-G31358

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

57.1 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human CCN4 / WISP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71215

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38 kDa

Price:

20 µg/$1,107

Select

CCN4 / WISP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102204

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.3 kDa

Price:

100 µg/$494

Select

Human CCN4 / WISP1 Protein (Recombinant) - LS-G87

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

38.1 kDa

Price:

5 µg/$268; 20 µg/$349

Select

Mouse CCN4 / WISP1 Protein (Recombinant His) (aa213-350) - LS-G15789

Source:

E. coli

Tag:

His

Molecular Weight:

17.0 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

Viewing 1-11 of 11 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.