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Unfortunately, the antibody (ID:167339) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CCM1 / KRIT1

KRIT1, ankyrin repeat containing

Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.

Gene Name: KRIT1, ankyrin repeat containing
Synonyms: KRIT1, CaM, CCM1, Krev interaction trapped 1
Target Sequences: NM_004912 NP_004903.2 O00522

Filtered By: None
Target
ccm1-krit1 (10)
Reactivity
Human (10)
Mouse (1)
Rat (1)
Application
WB (8)
ELISA (8)
IF (1)
Host
rabbit (9)
mouse (1)
Isotype
IgG (8)
IgG2a,l (1)
Clonality
monoclonal mc (1)
polyclonal pc (9)
Clone
2C7 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (4)
Epitope
aa6-34 (6)
aa5-34 (1)
Publications
No (10)
Showing 1-10 out of 10 results
Anti-CCM1 / KRIT1 Antibody LS-C346127

Rabbit Polyclonal (IgG) to Human CCM1 / KRIT1
Mouse, Rat, Human
IF WB
Unconjugated
Anti-CCM1 / KRIT1 Antibody (aa5-34) LS-C322549

Rabbit Polyclonal (IgG) to Human CCM1 / KRIT1
Human
ELISA WB
Unconjugated
Anti-CCM1 / KRIT1 Antibody (aa6-34, Biotin) LS-C236926

Rabbit Polyclonal (IgG) to Human CCM1 / KRIT1
Human
ELISA WB
Biotin Conjugated
Anti-CCM1 / KRIT1 Antibody (aa6-34, FITC) LS-C236927

Rabbit Polyclonal (IgG) to Human CCM1 / KRIT1
Human
ELISA WB
FITC Conjugated
Anti-CCM1 / KRIT1 Antibody (aa6-34, AP) LS-C236925

Rabbit Polyclonal (IgG) to Human CCM1 / KRIT1
Human
ELISA WB
AP Conjugated
Anti-CCM1 / KRIT1 Antibody (aa6-34, APC) LS-C236928

Rabbit Polyclonal (IgG) to Human CCM1 / KRIT1
Human
ELISA WB
APC Conjugated
Anti-CCM1 / KRIT1 Antibody (aa6-34, PE) LS-C236929

Rabbit Polyclonal (IgG) to Human CCM1 / KRIT1
Human
ELISA WB
PE Conjugated
Anti-CCM1 / KRIT1 Antibody (aa6-34, Azide-free, HRP) LS-C248668

Rabbit Polyclonal (IgG) to Human CCM1 / KRIT1
Human
ELISA WB
HRP Conjugated, Azide-free
Anti-CCM1 / KRIT1 Antibody (clone 2C7) LS-C196831

Mouse Monoclonal [clone 2C7] (IgG2a,l) to Human CCM1 / KRIT1
Human
ELISA
Unconjugated
Anti-CCM1 / KRIT1 Antibody LS-C662359

Rabbit Polyclonal to Human CCM1 / KRIT1
Human
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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