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CCL5 / RANTES

chemokine (C-C motif) ligand 5

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Gene Name: chemokine (C-C motif) ligand 5
Family/Subfamily: Intercrine , not assigned-Intercrine
Synonyms: CCL5, Chemokine (C-C motif) ligand 5, D17S136E, EoCP, T-cell specific protein p288, SCYA5, SISd, T cell-specific protein P228, Beta-chemokine RANTES, C-C motif chemokine 5, RANTES, SIS-delta, Small-inducible cytokine A5, T-cell-specific protein RANTES, TCP228
Target Sequences: NM_002985 NP_002976.2 P13501

Publications (2)

1
RANKL-Expressing Ectopic Extramammary Paget's Disease on the Lower Abdomen. Hagiwara-Takita A, Fujimura T, Kakizaki A, Aiba S. Case reports in dermatology. 2016 8:130-5. (IF; Human) [Full Text Article] [PubMed:27462221] [PMC:PMC4943311]
2
Glial- and Neuronal-Specific Expression of CCL5 mRNA in the Rat Brain. Lanfranco MF, Mocchetti I, Burns MP, Villapol S. Frontiers in neuroanatomy. 2018 January;11:137. (Mouse) [Full Text Article] [PubMed:29375328] [PMC:PMC5770405] Related Antibodies: LS-C104689.

☰ Filters
Products
Proteins (36)
Over-Expression Lysate (2)
Recombinant (32)
CCL5 / RANTES (36)
Animal-free (1)
No (36)
6His, N-terminus (3)
GST (2)
His (7)
His-GST (2)
His-S (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Bovine (1)
Dog (1)
Guinea pig (1)
Horse (1)
Human (22)
Mouse (4)
Pig (1)
Rat (3)
Rhesus monkey (1)
293T Cells (1)
E. coli (30)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (15)
Low endotoxin level (18)
Biologically active (11)
Animal-free (1)
CCL5 / RANTES Protein - Purified recombinant protein CCL5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
7.8 kDa
20 µg/$1,107
CCL5 / RANTES Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
10 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
E. coli
His
9.3 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Select
E. coli
None
Less than 0.01 EU/µg protein (determined by LAL method).
7.9 kDa
5 µg/$279; 20 µg/$354; 50 µg/$456; 100 µg/$634; 1000 µg/$2,337
Select
E. coli
None
Less than 0.01 EU/µg protein (determined by LAL method).
2 µg/$349; 10 µg/$718; 50 µg/$2,149; 100 µg/$3,596
CCL5 / RANTES Protein - Human T cells chemoattracted by CCL5.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 68 amino acid recombinant protein has a predicted molecular mass of approximately 7,851 Da. The DTT-reduced protein migrates at approximately 7kDa and the non-reduced protein migrates at approximately 9kDa by SDS-PAGE. The N-terminal amino acid is Ser
10 µg/$306; 25 µg/$383; 100 µg/$749
CCL5 / RANTES Protein - Baf3-hCCR5 transfectants chemoattracted by mouse CCL5.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 68 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced protein migrates at approximately 10 kD and non-reduced protein migrates at approximately 11 kD by SDS-PAGE. The predicted N-terminal amino acid
10 µg/$283; 25 µg/$359; 100 µg/$620
CCL5 / RANTES Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
9.99 kDa
20 µg/$150
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
7.8 kDa
1 mg/$2,880; 20 µg/$372
CCL5 / RANTES Protein - 12.5% SDS-PAGE of human CCL5 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
35.75 kDa
10 µg/$479; 25 µg/$670
CCL5 / RANTES Protein - Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted By SDS-PAGE
Select
E. coli
His
11.6 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
CCL5 / RANTES Protein - Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted By SDS-PAGE
Select
E. coli
His
11.6 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Select
E. coli
GST
35.2 kD
100 µg/$420; 20 µg/$323
Select
E. coli
His
11.9 kD
100 µg/$420; 20 µg/$323
Select
HEK 293 Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
8 kDa (SDS-PAGE)
5 µg/$253; 25 µg/$296
Select
None
7.8 kD
20 µg/$484
CCL5 / RANTES Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
9.99 kDa
100 µg/$494
Select
E. coli
His
Less than 0.1 EU/µg protein (determined by LAL method).
50 µg/$621
CCL5 / RANTES Protein
Select
E. coli
None
Biologically active
7.8 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
CCL5 / RANTES Protein
Select
E. coli
None
Biologically active
7.9 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5 µg/$268; 20 µg/$349
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5 µg/$268; 20 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 20 µg/$370
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.9 kDa
5 µg/$268; 20 µg/$349
Select
E. coli
67 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
7.48 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).