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CCL4 / MIP-1 Beta
chemokine (C-C motif) ligand 4
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
| Gene Name: | chemokine (C-C motif) ligand 4 |
| Family/Subfamily: | Intercrine , Intercrine beta |
| Synonyms: | CCL4, ACT2, Act-2, AT744.1, C-C motif chemokine 4, Chemokine (C-C motif) ligand 4, CC chemokine ligand 4, HC21, LAG1, MIP1B, MIP1B1, LAG-1, SCYA2, Secreted protein G-26, SIS-gamma, MIP-1-beta, MIP-1-beta(1-69), Small-inducible cytokine A4, T-cell activation protein 2, G-26, Lymphocyte-activation gene 1, PAT 744, Protein H400, SCYA4 |
| Target Sequences: | NM_002984 NP_002975.1 P13236 |
☰ Filters
Products
Proteins
(29)
Type
Over-Expression Lysate
(2)
Recombinant
(25)
Target
CCL4 / MIP-1 Beta
(29)
Publications
No
(29)
Tag
6His, N-terminus
(1)
GST, N-terminus
(1)
His
(3)
His-GST
(4)
His-GST-S
(1)
Human IgG1 Fc
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Dog
(1)
Human
(14)
Mouse
(5)
Pig
(1)
Rabbit
(1)
Rat
(5)
Source
293T Cells
(1)
CHO Cells
(1)
E. coli
(22)
HEK 293 Cells
(2)
Wheat Germ Extract
(1)
Yeast
(2)
Purification
Purified
(15)
Low Endotoxin Level
Low endotoxin level
(11)
Biologically Active
Biologically active
(12)
E. coli
His-GST
42.2 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
E. coli
None
Less than 0.01 EU/µg protein (determined by LAL method).
10.2 kDa
2 µg/$349; 10 µg/$718; 50 µg/$2,149; 100 µg/$3,596
E. coli
None
Less than 0.01 EU/µg protein (determined by LAL method).
7.8 kDa
5 µg/$279; 20 µg/$354; 50 µg/$456; 100 µg/$634; 1000 µg/$2,337
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 69 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced and non-reduced protein migrate at approximately 13 kD by SDS-PAGE. The predicted N-terminal amino acid is Ala.
10 µg/$352; 25 µg/$436; 100 µg/$744
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 69 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced and non-reduced protein migrate at approximately 13 kD by SDS-PAGE. The predicted N-terminal amino acid is Ala.
10 µg/$352; 25 µg/$436; 100 µg/$744
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His-GST-S
37.8 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His-GST
40.1 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
HEK 293 Cells
Myc-DDK (Flag)
10 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
10 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
10 kDa
100 µg/$494
Yeast
His
9.2 kDa
100 µg/$918
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$386
E. coli
None
Biologically active
7.8 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
None
Biologically active
7.8 kDa
10 µg/$388; 100 µg/$957; 500 µg/$1,747
E. coli
None
Biologically active
7.8 kDa
10 µg/$388; 100 µg/$957; 500 µg/$1,747
E. coli
None
Biologically active
7.8 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.6 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.7 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~8 kDa
10 µg/$291; 100 µg/$607; 1 mg/$2,551
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~8.1 kDa
10 µg/$291; 1 mg/$4,099
Viewing 1-25
of 29
product results
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