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CCL21 / SLC

chemokine (C-C motif) ligand 21

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Gene Name: chemokine (C-C motif) ligand 21
Family/Subfamily: Intercrine , Intercrine beta
Synonyms: CCL21, 6Ckine, Beta chemokine exodus-2, C-C motif chemokine 21, Beta-chemokine exodus-2, CKb9, ECL, Small-inducible cytokine A21, SCYA21, SLC, Exodus-2, TCA4
Target Sequences: NM_002989 NP_002980.1 O00585

Publications (4)

1
Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys. Dudal S, Subramanian K, Flandre T, Law WS, Lowe PJ, Skerjanec A, Genin JC, Duval M, Piequet A, Cordier A, Jarai G, Van Heeke G, Taplin S, Krantz C, Jones S, Warren AP, Brennan FR, Sims J, Lloyd P. mAbs. 2015 7:829-37. (WB; Human) [Full Text Article] [PubMed:26230385] [PMC:PMC4622749] Related Antibodies: LS-C104622.
2
Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy. Kühne L, Jung B, Poth H, Schuster A, Wurm S, Ruemmele P, Banas B, Bergler T. BMC immunology. 2017 December;18:52. (Mouse) [Full Text Article] [PubMed:29258420] [PMC:PMC5735914]
3
CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer. Kaiwen Li, Tiancheng Li, Zhaoyi Feng, Mei Huang, Lei Wei, Zhiyu Yan, Mark Long, Qiang Hu, Jianmin Wang, Song Liu, Dennis C Sgroi, Shadmehr Demehri. Science advances. 2021 June;7: [Full Text Article] [PubMed:34144976] [PMC:PMC8213232]
4
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells. Beth Lucas, Andrea J White, Emilie J Cosway, Sonia M Parnell, Kieran D James, Nick D Jones, Izumi Ohigashi, Yousuke Takahama, William E Jenkinson, Graham Anderson. Nature communications. 2020 May;11:2198. [Full Text Article] [PubMed:32366944] [PMC:PMC7198500] Related Antibodies: LS-C104634.
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Products
Proteins (19)
Over-Expression Lysate (2)
Recombinant (17)
CCL21 / SLC (19)
No (19)
6His, N-terminus (1)
GST (1)
His (1)
His-GST (1)
His-GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (9)
Mouse (7)
Rabbit (1)
Rat (1)
293T Cells (1)
E. coli (14)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (8)
Low endotoxin level (8)
Biologically active (8)
CCL21 / SLC Protein - Purified recombinant protein CCL21 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
12.2 kDa
20 µg/$1,107
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
12kD
10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157
CCL21 / SLC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
14.65 kDa
20 µg/$150
Select
E. coli
His
13.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
CCL21 / SLC Protein - Recombinant Secondary Lymphoid Tissue Chemokine By SDS-PAGE
Select
E. coli
His-GST, N-terminus
46.0 kDa
10 µg/$288; 50 µg/$482; 100 µg/$772; 200 µg/$965; 1 mg/$2,098; 500 µg/$1,627; 5 mg/$3,375; 2 mg/$2,288
CCL21 / SLC Protein - Recombinant Secondary Lymphoid Tissue Chemokine By SDS-PAGE
Select
E. coli
His-GST
40.9 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
CCL21 / SLC Protein - 12.5% SDS-PAGE of human CCL21 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
41 kDa
2 µg/$439
CCL21 / SLC Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
11 kDa
10 µg/$265; 50 µg/$315
CCL21 / SLC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
14.65 kDa
100 µg/$494
CCL21 / SLC Protein - Mouse CCL21 chemoattracts BaF3-hCCR7 transfectants.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 110 amino acid recombinant protein has a predicted molecular mass of approximately 12 kD. The DTT-reduced and non-reduced protein migrate at approximately 16 kD by SDS-PAGE. The N-terminal amino acid is Serine.
10 µg/$306; 25 µg/$375; 100 µg/$731
CCL21 / SLC Protein - BaF3-hCCR7 cells chemoattracted by human CCL21.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 111 amino acid recombinant protein has a predicted molecular mass of approximately 12 kD. The DTT-reduced protein migrates at approximately 16 kD and non-reduced protein at approximately 17 kD by SDS-PAGE. The N-terminal amino acid is Ser.
10 µg/$306; 25 µg/$375; 100 µg/$731; 500 µg/$1,614
CCL21 / SLC Protein - Recombinant Rabbit Exodus-2, also known as CCL21 detected using Chicken anti Rabbit Exodus-2 as the capture reagent and Chicken anti Rabbit Exodus-2:Biotin as the detection reagent followed by Streptavidin:HRP.
Select
Yeast
None
12.0 kDa
5 µg/$390
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
12.2 kDa
1 mg/$2,653; 20 µg/$364
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.0 kDa
10 µg/$281; 50 µg/$414
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~12 kDa
20 µg/$291; 100 µg/$490; 1 mg/$2,551
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~12 kDa
20 µg/$432; 1 mg/$4,915
CCL21 / SLC Protein
Select
E. coli
None
Biologically active
12.1 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
CCL21 / SLC Protein
Select
E. coli
None
Biologically active
12.2 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
12.0 kDa
5 µg/$268; 20 µg/$349
Viewing 1-19 of 19 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).