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CCL18 / PARC

chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.

Gene Name: chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Family/Subfamily: Intercrine , Intercrine beta
Synonyms: CCL18, AMAC1, Cc chemokine amac1, DC-CK1, Chemokine (C-C), dendritic, DCCK1, MIP-4, AMAC-1, MIP4, SCYA18, Small-inducible cytokine A18, C-C motif chemokine 18, Cc chemokine (amac)-1, CC chemokine ligand 18, CC chemokine PARC, CKb7, Dendritic cell chemokine 1, PARC, Small inducible cytokine A18
Target Sequences: NM_002988 NP_002979.1 P55774

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).