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CBX5 / HP1 Alpha

chromobox homolog 5

CBX5 / HP1 Alpha is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: chromobox homolog 5
Synonyms: CBX5, Chromobox homolog 5, HP1Hs alpha, HP1Hs-alpha, HP1, HP1 alpha homolog, HP1 alpha, HP1-ALPHA, HP1A, Antigen p25, Chromobox protein homolog 5
Target Sequences: NM_012117 NP_036249.1 P45973

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Products
Proteins (11)
Over-Expression Lysate (6)
Recombinant (5)
CBX5 / HP1 Alpha (11)
No (11)
GST (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (8)
Human (8)
293T Cells (3)
E. coli (2)
HEK 293 Cells (5)
Wheat Germ Extract (1)
Purified (2)
CBX5 / HP1 Alpha Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
CBX5 / HP1 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
22 kDa
20 µg/$150
CBX5 / HP1 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
22 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
22 kDa
20 µg/$150
CBX5 / HP1 Alpha Protein - Purified recombinant protein CBX5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
22 kDa
20 µg/$1,107
CBX5 / HP1 Alpha Protein - Purified recombinant protein CBX5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
22 kDa
20 µg/$1,107
CBX5 / HP1 Alpha Protein - 12.5% SDS-PAGE of human CBX5 stained with Coomassie Blue
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Wheat Germ Extract
GST
46.75 kDa
10 µg/$479; 25 µg/$670
CBX5 / HP1 Alpha Protein
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E. coli
His, N-Terminal
22 kDa
50 µg/$419
CBX5 / HP1 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
22 kDa
100 µg/$494
CBX5 / HP1 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22 kDa
100 µg/$494
CBX5 / HP1 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).