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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CBX4

chromobox homolog 4

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene Name: chromobox homolog 4
Synonyms: CBX4, Chromobox homolog 4, Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, NBP16, NS5ATP1-binding protein 16, HPC2, Polycomb 2 homolog, PC2, Pc class 2 homolog
Target Sequences: NM_003655 NP_003646.2 O00257

Filtered by: None
Target
CBX4 (51)
Reactivity
Human (51)
Mouse (26)
Rat (8)
Bat (4)
Bovine (8)
Chicken (4)
Chimpanzee (6)
Dog (8)
Gibbon (6)
Guinea pig (8)
Horse (4)
Monkey (9)
Pig (8)
Rabbit (8)
Xenopus (4)
Application
IHC (21)
IHC-P (10)
WB (46)
Flo (1)
ELISA (29)
ICC (7)
IF (10)
IP (8)
Host
rabbit (48)
mouse (3)
Isotype
IgG (38)
IgG1 (3)
Clonality
monoclonal mc (3)
polyclonal pc (48)
Clone
6C5G3 (1)
Format
AP Conjugated (3)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (6)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (26)
Epitope
aa1-30 (8)
aa410-437 (8)
aa80-110 (8)
aa31-80 (4)
aa53-102 (4)
aa150-200 (2)
aa8-65 (2)
aa401-560 (1)
aa95-107 (1)
Publications
No (51)
Showing 1-25 of 51 results

IHC-plus™ CBX4 Antibody (aa95-107) LS-B128
Rabbit Polyclonal (IgG) to Human CBX4
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg 1.36mg/ml  $485.00
Anti-CBX4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-hPC2 Antibody - Immunofluorescence Microscopy. anti-hPC2 antibody was used for immunofluorescent imaging of human cells (U2OS). The image reveals the expected discrete nuclear structure that is termed the PcG body corresponding to the known localization of PC2 (see Satijn et al. below). IF was performed after fixation in PBS with 4% PF for 5 min, permeabilization with 0.5% Triton X100-PBS for 5 min, and blocking with 5% milk / 0.2% Tween for 1 h. Primary antibody used at 1:200 in 5% milk / 0.2% Tween for 1 h, secondary antibody for 30 min. All blocking and incubation steps carried out at 37° C. Nuclei were counterstained with Hoechst stain (blue). Data contributed by Luke Hughes-Davies and Rhiannon Jade, Gurdon Institute, Cambridge, UK.

CBX4 Antibody LS-C334570
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
IHC, IP, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded human lung cancer tissue.
Western blot analysis of extracts of various cell lines.

CBX4 Antibody (aa401-560) LS-C375398
Rabbit Polyclonal (IgG) to Human CBX4
Human
ELISA, IHC, IHC-P
Unconjugated
50µl 2.33mg/ml  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human colorectal carcinoma using antibody at 1:100 dilution.

IHC-plus™ CBX4 Antibody (aa150-200) LS-B12341
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50µl 1mg/ml  $425.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

CBX4 Antibody (aa80-110) LS-C327027
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
200µl  $590.00

CBX4 Antibody (aa80-110, Biotin) LS-C275987
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200µl  $740.00

CBX4 Antibody (aa80-110, FITC) LS-C275989
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200µl  $740.00

CBX4 Antibody (aa80-110, APC) LS-C275986
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200µl  $740.00

CBX4 Antibody (aa80-110, Azide-free, HRP) LS-C275988
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

CBX4 Antibody (aa80-110, PE) LS-C275990
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200µl  $740.00

CBX4 Antibody (aa80-110, AP) LS-C275981
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200µl  $740.00

IHC-plus™ CBX4 Antibody (aa150-200) LS-B12407
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
IHC, IHC-P
Unconjugated
50µl  $425.00
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ CBX4 Antibody (aa53-102) LS-B11869
Rabbit Polyclonal (IgG) to Human CBX4
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CBX4 Antibody (aa53-102, HRP) LS-C425522
Rabbit Polyclonal (IgG) to Human CBX4
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CBX4 Antibody (aa53-102, Biotin) LS-C425558
Rabbit Polyclonal (IgG) to Human CBX4
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CBX4 Antibody (aa53-102, FITC) LS-C425606
Rabbit Polyclonal (IgG) to Human CBX4
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $385.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ CBX4 Antibody LS-B8138
Rabbit Polyclonal (IgG) to Human CBX4
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-HPC2 / CBX4 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Western blot Image

CBX4 Antibody LS-C661691
Rabbit Polyclonal (IgG) to Human CBX4
Human
ELISA, IHC, IP, WB
Unconjugated
100µg  $405.00

CBX4 Antibody LS-C482538
Rabbit Polyclonal to Human CBX4
Mouse, Human
ICC, IF, WB
Unconjugated
50µl 1mg/ml  $255.00; 100µl 1mg/ml  $295.00; 200µl 1mg/ml  $375.00
Immunofluorescent analysis of CBX4 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
Western blot analysis of CBX4 expression in MCF7 (A); HepG2 (B); Jurkat (C); mouse liver (D) whole cell lysates.

CBX4 Antibody LS-C153640
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
0.1mg 1mg/ml  $365.00
Immunofluorescence of CBX4 in human brain tissue with CBX4 antibody at 20 ug/ml.
Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

CBX4 Antibody LS-C765150
Rabbit Polyclonal (IgG) to Human CBX4
Mouse, Human
IHC, IP, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

CBX4 Antibody (clone 6C5G3) LS-C669290
Mouse Monoclonal [clone 6C5G3] (IgG1) to Human CBX4
Human
ELISA, Flo
Unconjugated
0.1mg  $365.00

CBX4 Antibody (aa80-110) LS-C98481
Rabbit Polyclonal to Human CBX4
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
The anti-CBX4 N-term antibody is used in Western blot to detect CBX4 in mouse kidney tissue lysate.

CBX4 Antibody LS-C341975
Rabbit Polyclonal to Human CBX4
Human
IHC, WB
Unconjugated
100µl 1mg/ml  $385.00

CBX4 Antibody (aa410-437) LS-C320025
Rabbit Polyclonal (IgG) to Human CBX4
Human
ELISA, WB
Unconjugated
200µl  $590.00
Showing 1-25 of 51 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).