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CBX3 / HP1 Gamma

chromobox homolog 3

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Gene Name: chromobox homolog 3
Synonyms: CBX3, Chromobox homolog 3, HP1Hs-gamma, Heterochromatin-like protein 1, Modifier 2 protein, HP1-GAMMA, Chromobox protein homolog 3, HECH, HP1 gamma, HP1 gamma homolog
Target Sequences: NM_016587 NP_057671.2 Q13185

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Products
Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
CBX3 / HP1 Gamma (10)
No (10)
GST (1)
His (3)
His, N-Terminal (1)
Myc-DDK (Flag) (5)
Human (7)
Mouse (1)
293T Cells (2)
E. coli (4)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (2)
CBX3 / HP1 Gamma Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
CBX3 / HP1 Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.6 kDa
100 µg/$494
CBX3 / HP1 Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.6 kDa
100 µg/$494
CBX3 / HP1 Gamma Protein
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E. coli
His, N-Terminal
20.6 kDa
50 µg/$419
CBX3 / HP1 Gamma Protein - 12.5% SDS-PAGE of human CBX3 stained with Coomassie Blue
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Wheat Germ Extract
GST
45.87 kDa
10 µg/$479; 25 µg/$670
CBX3 / HP1 Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.6 kDa
20 µg/$150
CBX3 / HP1 Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.6 kDa
20 µg/$150
CBX3 / HP1 Gamma Protein - Purified recombinant protein CBX3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.6 kDa
20 µg/$1,107
CBX3 / HP1 Gamma Protein - Recombinant Chromobox Homolog 3 By SDS-PAGE
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E. coli
His
22.3 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
CBX3 / HP1 Gamma Protein - Recombinant Chromobox Homolog 3 By SDS-PAGE
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E. coli
His
22.4 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).