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CBX2

chromobox homolog 2

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.

Gene Name: chromobox homolog 2
Synonyms: CBX2, Chromobox homolog 2, Chromobox protein homolog 2, M33, SRXY5, CDCA6, Modifier 3, Pc class homolog
Target Sequences: NM_005189 NP_116036.1 Q14781

Publications (1)

1
Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter. Sun D, Cao X, Wang C. Protein & cell. 2019 April;10:285-294. [Full Text Article] [PubMed:30357595] [PMC:PMC6418077] Related Antibodies: LS-C81651.

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Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
CBX2 (7)
No (7)
GST, N-terminus (2)
His, N-Terminal (1)
Myc-DDK (Flag) (4)
Human (5)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
CBX2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CBX2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CBX2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
55.9 kDa
20 µg/$215
CBX2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
23.1 kDa
20 µg/$150
CBX2 Protein
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E. coli
His, N-Terminal
23.1 kDa
50 µg/$419
CBX2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
55.9 kDa
100 µg/$710
CBX2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
23.1 kDa
100 µg/$494
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).