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CBS

cystathionine-beta-synthase

Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.

Gene Name: cystathionine-beta-synthase
Synonyms: CBS, Beta-thionase, Cystathionine beta-synthase, HIP4, Methylcysteine synthase, Serine sulfhydrase, Cystathionine-beta-synthase
Target Sequences: NM_000071 NP_000062.1 P35520

Publications (1)

1
The H2S-generating enzymes cystathionine ß-synthase and cystathionine ?-lyase play a role in vascular development during normal lung alveolarization. Madurga A, Golec A, Pozarska A, Ishii I, Mižíková I, Nardiello C, Vadász I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE. American journal of physiology. Lung cellular and molecular physiology. 2015 October;309:L710-L724. [Full Text Article] [PubMed:26232299]

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Products
Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
CBS (12)
No (12)
6His, N-terminus (3)
6His-SUMO, N-terminus (1)
GST (2)
GST, N-terminus (2)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (8)
Mouse (3)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (4)
Yeast (1)
Purified (5)
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E. coli
6His, N-terminus
64.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CBS Protein - Purified recombinant protein CBS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
60.4 kDa
20 µg/$1,107
CBS Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
1 mg/$1,973; 100 µg/$570; 20 µg/$395
CBS Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CBS Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CBS Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
CBS Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
CBS Protein
Select
E. coli
His-SUMO
61.41 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CBS Protein - 12.5% SDS-PAGE of human CBS stained with Coomassie Blue
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Wheat Germ Extract
GST
86.35 kDa
10 µg/$479; 25 µg/$670
CBS Protein - 12.5% SDS-PAGE of human CBS stained with Coomassie Blue
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Wheat Germ Extract
GST
86.35 kDa
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
60.4 kDa
20 µg/$150
CBS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
60.4 kDa
100 µg/$494
Viewing 1-12 of 12 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).