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CBLN1 / Cerebellin 1

cerebellin 1 precursor

Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion.

Gene Name: cerebellin 1 precursor
Synonyms: CBLN1, CLN1, Cerebellin, Cerebellin 1 precursor, Precerebellin, Cerebellin-1
Target Sequences: NM_004352 NP_004343.1 P23435

Publications (2)

1
Chronic hyperoxia alters the expression of neurotrophic factors in the carotid body of neonatal rats. Dmitrieff EF, Wilson JT, Dunmire KB, Bavis RW. Respiratory Physiology & Neurobiology. 2011 175:220-7. (IHC-Fr; Rat) [Full Text Article] [PubMed:21094282] [PMC:PMC3033470] Related Antibodies: LS-B478.
2
Altered Cerebellar Circuitry following Thoracic Spinal Cord Injury in Adult Rats. Visavadiya NP, Springer JE. Neural plasticity. 2016 2016:8181393. (WB; Human) [Full Text Article] [PubMed:27504204] [PMC:PMC4967704] Related Antibodies: LS-C119839.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
CBLN1 / Cerebellin 1 (4)
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His-GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
CBLN1 / Cerebellin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
100 µg/$494
CBLN1 / Cerebellin 1 Protein - Recombinant  Cerebellin 1 By SDS-PAGE
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E. coli
His-GST
49.0 kDa
10 µg/$275; 50 µg/$407; 100 µg/$652; 200 µg/$812; 1 mg/$1,893; 500 µg/$1,444; 5 mg/$2,843; 2 mg/$2,077
CBLN1 / Cerebellin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$150
CBLN1 / Cerebellin 1 Protein - Purified recombinant protein CBLN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$1,107
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).