CBLC

Cbl proto-oncogene C, E3 ubiquitin protein ligase

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

☰ Filters

Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

CBLC (7)

Publications

No (7)

Tag

GST (1)

His-GST (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Source

293T Cells (2)

Baculovirus (1)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

Select

CBLC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125135

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.2 kDa

Price:

100 µg/$494

Select

Human CBLC Protein (Recombinant GST) (Full Length) - LS-G32925

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.88 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human CBLC Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69766

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.3 kDa

Price:

20 µg/$1,107

Select

Human CBLC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85492

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.3 kDa

Price:

20 µg/$150

Select

Human CBLC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85491

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.2 kDa

Price:

20 µg/$150

Select

CBLC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101031

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.3 kDa

Price:

100 µg/$494

Select

Human CBLC Protein (Recombinant His-GST) (Met1-Ala474) - LS-G97229

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

80.2 kDa

Price:

100 µg/$843

Viewing 1-7 of 7 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.