CBLB

Cbl proto-oncogene B, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

CBLB (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CBLB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81486

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.3 kDa

Price:

20 µg/$150

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Human CBLB Protein (Recombinant GST, N-terminus) (aa21-129) - LS-G58009

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CBLB Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68121

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.3 kDa

Price:

20 µg/$1,107

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Human CBLB Protein (Recombinant GST) (Full Length) - LS-G27761

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

135.8 kDa

Price:

2 µg/$439

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CBLB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102413

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.3 kDa

Price:

100 µg/$494

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